Clinical study of alginate gel dressing applied in gynecology against human papillomavirus (HPV) infection
褐藻酸盐凝胶敷料应用于妇科抗人乳头瘤病毒(HPV)感染的临床研究

摘要

目的 探究分析褐藻酸盐凝胶敷料应用于妇科抗人乳头瘤病毒(HPV)感染的临床效果。方法 选取2024年1月至2024年12月期间，院内抗人乳头瘤病毒(HPV)感染患者共102例，作为此次研究对象，结合患者出生日期，通过随机数表法，将102例患者随机分为对照组与观察组。对照组采用常规治疗，观察组应用褐藻酸盐凝胶敷料落实治疗，对比两组免疫功能状态，HPV转变情况以及生活质量。结果 治疗前两组CD3+、CD4+，CD8+指标，HPV病毒载量以及SF-36评分对比，无统计学意义，P＞0.05。治疗后观察组CD3+、CD4+水平高于对照组，CD8+水平低于对照组，P＜0.05。观察组HPV病毒载量低于对照组，HPV转阴率高于对照组，P＜0.05。治疗后观察组SF-36评分高于对照组，P＜0.05。结论 褐藻酸盐凝胶敷料可显著改善患者免疫功能状态，HPV转变情况以及生活质量，值得推广与应用。

Abstract

Objective To explore and analyze the clinical effect of alginate gel dressing in gynecological anti human papillomavirus (HPV) infection.
Methods A total of 102 patients with anti human papillomavirus (HPV) infection in the hospital from January 2024 to December 2024 were selected as the study subjects. Combined with the patients' date of birth, the 102 patients were randomly divided into a control group and an observation group using a random number table method. The control group was treated with routine treatment, and the observation group was treated with alginate gel dressing. The immune function, HPV transformation and quality of life of the two groups were compared. The comparison of CD3+, CD4+, CD8+indicators, HPV viral load, and SF-36 score between the two groups before treatment showed no statistical significance, P＞0.05. After treatment, the observation group had higher levels of CD3+and CD4+compared to the control group, and lower levels of CD8+compared to the control group, P＜0.05. The HPV viral load in the observation group was lower than that in the control group, and the HPV seroconversion rate was higher than that in the control group, P＜0.05. After treatment, the SF-36 score of the observation group was higher than that of the control group, P＜0.05.
Conclusion   The alginate gel dressing can significantly improve the immune function, HPV transformation and quality of life of patients, which is worth popularizing and applying.