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国际临床研究杂志

International Journal of Clinical Research

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International Journal of Clinical Research. 2025; 9: (5) ; 10.12208/j.ijcr.20250237 .

Research progress on the relationship between EME1-mediated AKT signaling pathway and colorectal cancer
EME1介导AKT信号通路与结肠癌的关系研究进展

作者： 罗可宛1, 刘博伦2, 李珊珊2, 黄子璇3, 黄胜利2 *

1 华北理工大学中医学院 河北唐山

2 华北理工大学附属医院胃肠肿瘤外科 河北唐山

3 华北理工大学临床医学院 河北唐山

*通讯作者： 黄胜利,单位： 华北理工大学附属医院胃肠肿瘤外科 河北唐山；

引用本文: 罗可宛, 刘博伦, 李珊珊, 黄子璇, 黄胜利 EME1介导AKT信号通路与结肠癌的关系研究进展[J]. 国际临床研究杂志, 2025; 9: (5) : 66-69.
Published: 2025/5/26 11:20:26

摘要

结肠癌是常见消化系统恶性肿瘤之一，其发病机制涉及多个过程，而DNA损伤修复便是其中之一。EME1基因是DNA损伤修复基因之一，其变异和缺失可增加肿瘤易感性，已报道与多种肿瘤相关。故抑制EME1 基因介导的DNA 损伤修复机制有可能提高肿瘤化疗的敏感性，为结肠癌临床诊治提供一个有效的分子标志物和治疗靶点。

关键词： EME1；AKT信号通路；结肠癌

Abstract

Colorectal cancer is one of the common malignant tumors of the digestive system, and its pathogenesis involves multiple processes, including DNA damage repair. The EME1 gene is one of the DNA damage repair genes; its mutations and deletions can increase tumor susceptibility and have been reported to be associated with various tumors. Therefore, inhibiting the DNA damage repair mechanism mediated by the EME1 gene may enhance the sensitivity of chemotherapy for tumors, providing an effective molecular marker and therapeutic target for clinical diagnosis and treatment of colorectal cancer.

Key words： EME1; AKT signaling pathway; Colorectal cancer

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