International Journal of Clinical Research
International Journal of Clinical Research. 2025; 9: (5) ; 10.12208/j.ijcr.20250228 .
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承德医学院附属医院 河北承德
*通讯作者： 傅华,单位：承德医学院附属医院 河北承德；
肝细胞癌（HCC）是我国癌症相关死亡的主要原因之一，多数患者确诊时已处于中晚期，丧失手术机会。转化治疗通过靶向、免疫及局部治疗联合策略，使不可切除肝癌降期，为患者争取手术可能。其中，仑伐替尼等靶向药物联合免疫治疗显著提高了客观缓解率，但耐药机制（如EGFR、VEGFR、FGFR及Wnt/β-catenin通路异常）仍制约疗效。未来需探索多学科联合策略，克服耐药并优化个体化治疗，以改善患者预后。
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality in China, with most patients diagnosed at advanced stages and thus ineligible for surgical resection. Conversion therapy, employing combined strategies of targeted therapy, immunotherapy, and local treatment, enables tumor downstaging in initially unresectable HCC, potentially rendering patients eligible for curative surgery. Notably, lenvatinib-based targeted therapy combined with immunotherapy has significantly improved objective response rates. However, resistance mechanisms—including dysregulation of EGFR, VEGFR, FGFR, and Wnt/β-catenin signaling pathways—remain a major therapeutic limitation. Future research should focus on multidisciplinary strategies to overcome drug resistance and optimize personalized treatment, thereby improving patient outcomes.
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