Clinical adjunctive effect of Angong Niuhuang wan combined with conventional treatment in large vessel VaD patients a study
安宫牛黄丸结合常规治疗对大血管性VaD 患者的临床辅助效果研究

摘要

安宫牛黄丸（Angong Niuhuang Pill, ANP）是一种传统中药，因其清热解毒、镇惊开窍的作用在临床中广泛应用。研究表明，安宫牛黄丸在治疗血管性痴呆（Vascular Dementia, VaD），尤其是大血管性病变方面，具有一定的辅助治疗潜力。目的 评估安宫牛黄丸联合常规治疗对大血管性VaD患者的临床辅助效果，并基于多维度框架构建评价模型。方法 从“患者个体差异、用药情况、治疗方法、生活方式、医疗环境与支持系统”五个维度构建评价指标体系，采用层次分析法建立安宫牛黄丸联合常规治疗的临床辅助效果评价模型，并以浙江省台州市某医院的患者数据为例进行实证分析。结果 研究结果表明，安宫牛黄丸联合常规治疗对大血管性VaD患者具有显著的临床辅助效果。结论 本研究证实了安宫牛黄丸作为大血管性VaD辅助治疗的有效性，所提出的评价模型为评估该患者群体的治疗效果提供了全面的框架。

Abstract

Background Angong Niuhuang Pill (ANP), a traditional Chinese medicine, is widely used in clinical practice for its effects in clearing heat, detoxifying, calming convulsions, and restoring consciousness. It has shown potential as an adjunctive treatment for Vascular Dementia (VaD), particularly in cases involving large vessel disease. Objective To evaluate the clinical adjunctive effects of ANP combined with conventional therapy in patients with large vessel VaD, and to establish an evaluation model based on a multi-dimensional framework.
Methods An evaluation index system was constructed based on five dimensions: individual patient differences, medication usage, treatment methods, lifestyle factors, and healthcare environment and support systems. The Analytic Hierarchy Process was applied to develop an evaluation model for assessing the clinical adjunctive effects of ANP combined with conventional therapy. Empirical analysis was conducted using patient data from a hospital in Taizhou, Zhejiang Province.
Results The results demonstrated that ANP combined with conventional therapy has significant clinical adjunctive effects in patients with large vessel VaD.
Conclusion   The study highlights the potential of ANP as an effective adjunctive treatment for large vessel VaD when used in combination with conventional therapy. The proposed evaluation model provides a comprehensive framework for assessing treatment outcomes in this patient population.