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国际临床研究杂志

International Journal of Clinical Research

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International Journal of Clinical Research. 2025; 9: (4) ; 10.12208/j.ijcr.20250184 .

Research progress on the role of lipid ratio indicators in the estimation of cardiovascular disease risk
血脂比值指标在心血管疾病风险预估中的研究进展

作者： 李雅甜1, 李宏伟1, 李继舟1, 张晔2, 杨红玲2 *

1 大理大学临床医学院 云南大理

2 云南省第三人民医院 云南昆明

*通讯作者： 杨红玲,单位： 云南省第三人民医院 云南昆明；

引用本文: 李雅甜, 李宏伟, 李继舟, 张晔, 杨红玲 血脂比值指标在心血管疾病风险预估中的研究进展[J]. 国际临床研究杂志, 2025; 9: (4) : 50-55.
Published: 2025/4/30 10:30:10

摘要

血脂异常是引发心血管疾病（CVD）的关键因素之一，其中低密度脂蛋白胆固醇（LDL-C）水平长期以来被视为心血管疾病风险评估的核心指标。然而，近年来的研究表明，血脂比值指标在预测心血管疾病风险方面可能比单一血脂指标（如LDL-C）更具优势。这些血脂比值指标，如载脂蛋白B与载脂蛋白A1比值（ApoB/ApoA1）、非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值（non-HDL-C/HDL-C）、残余胆固醇与高密度脂蛋白胆固醇比值（RC/HDL-C）以及低密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值（LDL-C/HDL-C），在临床应用中可为心血管疾病风险评估提供更精确的工具。

关键词： 血脂比值指标；心血管疾病；预测

Abstract

Dyslipidemia is one of the key factors contributing to cardiovascular diseases (CVD), with low-density lipoprotein cholesterol (LDL-C) levels long regarded as a central metric for assessing cardiovascular risk. However, recent studies suggest that lipid ratio indices may offer superior predictive value for cardiovascular risk compared to single lipid metrics such as LDL-C. These lipid ratio indices, including the apolipoprotein B to apolipoprotein A1 ratio (ApoB/ApoA1), non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (non-HDL-C/HDL-C), remnant cholesterol to high-density lipoprotein cholesterol ratio (RC/HDL-C), and low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (LDL-C/HDL-C), provide more precise tools for cardiovascular risk assessment in clinical practice.

Key words： Lipid ratio indices, Cardiovascular diseases, Risk prediction

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