Clinical efficacy analysis of continuous blood purification therapy for severe sepsis
连续性血液净化治疗重症脓毒症的临床效果分析

摘要

目的 分析连续性血液净化疗法用于重症脓毒症中所起到的作用。方法 随机均分2023年12月-2024年12月本院接诊重症脓毒症病人（n=80）。试验组采取连续性血液净化疗法，对照组行常规治疗。对比不良反应等指标。结果 关于尿素氮和肌酐：治疗后，试验组低至（12.83±3.04）mmol/L、（149.71±24.31）umol/L，对照组高达（18.53±3.25）mmol/L、（176.23±27.19）umol/L，差异显著P＜0.05）。总有效率：试验组97.5%，对照组77.5%，P＜0.05。CRP和IL-10：治疗后：试验组（50.04±7.28）mg/L、（38.92±6.03）ug/L，对照组（57.93±8.14）mg/L、（35.17±3.34）ug/L，差异显著（P＜0.05）。不良反应：试验组2.5%，对照组17.5%，P＜0.05。结论 重症脓毒症病人用连续性血液净化疗法，效果显著，肾功能与炎症因子改善情况也更好，不良反应更少。

Abstract

Objective To analyze the role of continuous blood purification therapy in severe sepsis.
Methods Randomly divide patients with severe sepsis admitted to our hospital from December 2023 to December 2024 (n=80). The experimental group received continuous blood purification therapy, while the control group received routine treatment. Compare indicators such as adverse reactions.
Results Regarding urea nitrogen and creatinine: After treatment, the experimental group decreased to (12.83 ± 3.04) mmol/L and (149.71 ± 24.31) umol/L, while the control group increased to (18.53 ± 3.25) mmol/L and (176.23 ± 27.19) umol/L, with significant differences (P<0.05). The total effective rate was 97.5% in the experimental group and 77.5% in the control group, P＜0.05. CRP and IL-10: After treatment: the experimental group had (50.04 ± 7.28) mg/L and (38.92 ± 6.03) ug/L, while the control group had (57.93 ± 8.14) mg/L and (35.17 ± 3.34) ug/L, with significant differences (P<0.05). Adverse reactions: 2.5% in the experimental group and 17.5% in the control group, P＜0.05.
Conclusion   Continuous blood purification therapy has significant effects on severe sepsis patients, with better improvement in renal function and inflammatory factors, and fewer adverse reactions.