The level and clinical correlation of NT-proBNP in patients with chronic heart failure complicated with atrial fibrillation in plateau area
高原地区慢性心衰合并房颤患者NT-proBNP水平及临床相关性研究

摘要

目的 对高原地区慢性心力衰竭伴房颤患者的NT-proBNP水平及其临床相关性进行初步研究。方法对高原地区的200例慢性心力衰竭患者的住院病历资料进行了回顾性研究，将患者分为房颤组与非房颤组，并进行对比分析。结果 共纳入200例慢性心力衰竭患者，发现房颤组与非房颤组在NT-proBNP水平、左心房内径、左心室舒张末内径及左心室射血分数方面具有统计学差异（p＜0.05）；慢性心力衰竭患者NT-proBNP水平与左心房内径呈正相关（r=0.63 p＜0.05），与左心室舒张末内径呈负相关（r=-0.16 p＜0.05），与左心室射血分数也呈负相关（r=-0.28 p＜0.05）。结论 在慢性心力衰竭的临床评估中，NT-proBNP水平可反映心室的重构及心功能情况；当慢性心力衰竭患者合并出现房颤时，其NT-proBNP水平会进一步升高，因此该指标可以作为高原地区慢性心力衰竭合并房颤患者早期预测的参考依据。

Abstract

Objective To study the level of NT-proBNP and its clinical correlation in chronic heart failure patients with atrial fibrillation in high altitude area.
Methods The inpatient records of 200 patients with chronic heart failure in plateau area were retrospectively studied, and the patients were divided into atrial fibrillation group and non-atrial fibrillation group.
Results A total of 200 patients with chronic heart failure were included. It was found that there were statistical differences in NT-proBNP level, left atrial diameter, left ventricular end-diastolic diameter and left ventricular ejection fraction between AF group and non-AF group (p < 0.05). The level of NT-proBNP in patients with chronic heart failure was positively correlated with left atrial diameter (r=0.63 p < 0.05), negatively correlated with left ventricular end-diastolic diameter (r=-0.16 p < 0.05), and negatively correlated with left ventricular ejection fraction (r=-0.28 p < 0.05).
Conclusion   In the clinical evaluation of chronic heart failure, the level of NT-proBNP can reflect ventricular remodeling and cardiac function. When chronic heart failure patients with atrial fibrillation, the level of NT-proBNP will be further increased, so this index can be used as a reference for early prediction of chronic heart failure patients with atrial fibrillation in plateau areas.