International Journal of Clinical Research
International Journal of Clinical Research. 2025; 9: (4) ; 10.12208/j.ijcr.20250200 .
总浏览量: 79
1 华北理工大学附属医院胃肠肿瘤外科 河北唐山
2 华北理工大学 河北唐山
3 中国人民解放军空军军医大学第一附属医院肝胆外科 陕西西安
*通讯作者： 范斌,单位： 中国人民解放军空军军医大学第一附属医院肝胆外科 陕西西安；
急性胰腺炎临床症状通常表现为急性的上腹痛、恶心、呕吐、发热和血尿淀粉酶升高以及腰背部的疼痛，重症患者可能出现休克甚至死亡。急性胰腺炎早期可合并多器官损害，而胃损害更是临床常见器官损害之一。一般情况下患者会随着胰腺炎的好转，腹痛会随之减轻或消失。但临床研究发现部分患者在急性胰腺炎的有关检测指标已达正常后腹部疼痛仍持续存在较长时间。行胃镜检查发现这些患者合并活动性胃炎或消化性溃疡，其腹痛减轻或消失的时间较无胃损害的急性胰腺炎慢而且差异显著。对于急性胰腺炎相关性胃损伤治疗，传统西医治疗效果好，主要是以重点涉及根除Hp、抑酸剂、促动力药和胃黏膜保护剂以减轻症状为主，但是鉴于长期治疗的不良反应，导致断药后易复发。中医药物毒副作用小，可减轻全身炎症反应所导致的器官功能损伤，使得总体病死率大大降低，但其见效相对来说较慢。而中西医结合治疗，可减少西药的用药剂量及延长疗程，因此较好地规避了西医的不良反应及中医的见效慢等问题。
The clinical symptoms of acute pancreatitis are usually acute upper abdominal pain, nausea, vomiting, fever and elevated hematuria amylase, and pain in the low back, and severe patients may experience shock or even death. Acute pancreatitis can be combined with multiple organ damage in the early stage, and gastric damage is one of the common clinical organ damage. In general, as the pancreatitis improves, the abdominal pain will decrease or disappear. However, clinical studies have found that some patients have persistent abdominal pain for a long time after the detection index of acute pancreatitis has reached a normal level. Gastroscopy revealed that these patients had active gastritis or peptic ulcer, and the loss of abdominal pain was slower and significantly different than acute pancreatitis without gastric damage. For the treatment of acute pancreatitis-related gastric injury, the traditional western medicine treatment has good results, mainly involving the eradication of Hp, acid suppressor, prokinetic agent and gastric mucosal protective agent to reduce symptoms. However, in view of the adverse reactions of long-term treatment, it is easy to relapse after drug interruption. TCM drugs have little toxic and side effects, which can reduce the organ function damage caused by the systemic inflammatory reaction, making the overall case fatality rate greatly reduced, but its effect is relatively slow. The combined treatment of traditional Chinese and western medicine can reduce the dosage of western medicine and extend the course of treatment, so it better avoids the adverse reactions of western medicine and the slow effect of traditional Chinese medicine.
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