Study on the correlation between platelet antibodies and habitual miscarriage
血小板抗体与习惯性流产的相关性研究

摘要

目的 探讨血小板特异性和组织相关融性（HLA)抗体（即血小板抗体）与习惯性流产的相关性。方法 应用固相凝集法对760名无早期流产史孕妇及52名有早期流产史患者进行血小板抗体的筛选和调查。结果 760名无早期流产史孕妇中，检出血小板抗体阳性28例（3.68％），52名有早期流产史的患者，检出血小板抗体阳性11例（21.2％），有早期流产史患者血小板抗体阳性率显著高于对无早期流产史孕妇（χ2＝4.836，P<0.05）。39例血小板抗体阳性者中有11例有早期流产史，流产率为28.20％；773例血小板抗体阴性孕妇中，41例有早期流产，流产率为5.30％，说明血小板抗体与早期流产有显著相关性（r＝37.20，P＜0.05）。结论 血小板抗体阳性孕妇发生早期流产的风险较无血小板抗体者高。

Abstract

Objective To explore the correlation between platelet specific and tissue-specific fusion (HLA) antibodies (i.e. platelet antibodies) and habitual miscarriage.
Methods Solid phase agglutination assay was used to screen and investigate platelet antibodies in 760 pregnant women without a history of early miscarriage and 52 patients with a history of early miscarriage.
Results Among 760 pregnant women without a history of early miscarriage, 28 cases (3.68%) were detected as positive for platelet antibodies. Among 52 patients with a history of early miscarriage, 11 cases (21.2%) were detected as positive for platelet antibodies. The positive rate of platelet antibodies in patients with a history of early miscarriage was significantly higher than that in pregnant women without a history of early miscarriage (χ2=4.836, P<0.05). Among the 39 platelet antibody positive individuals, 11 had a history of early miscarriage, with a miscarriage rate of 28.20%; Among 773 pregnant women with negative platelet antibodies, 41 had early miscarriage, with a miscarriage rate of 5.30%, indicating a significant correlation between platelet antibodies and early miscarriage (r=37.20, P<0.05).
Conclusion   Pregnant women with positive platelet antibodies have a higher risk of early miscarriage compared to those without platelet antibodies.