Observation on the efficacy of dexmedetomidine instead of propofol in male patients with urinary system
右美托咪定代替丙泊酚用于泌尿系男患者疗效观察

摘要

目的 本研究调查分析右美托咪定代替丙泊酚用于泌尿系男患者疗效观察。方法 研究对象为2024年1月至2024年12月期间，我院泌尿外科住院100例男性患者。被随机分配接受右美托咪定组（观察组）和丙泊酚静脉麻醉组（对照组）每组50人。麻醉诱导用咪达唑伦0.1mg/kg代替丙泊酚，麻醉维持用右美托咪定0.4ug/Kg/h代替丙泊酚。通过测量两组患者的麻醉前后心率（HR）、平均动脉压（MAP）、血氧饱和度（SpO2）指标来评估恢复情况。记录手术过程中阴茎勃起的发生情况以及阴茎勃起从开始到结束的时间。结果 术中丙泊酚全静脉麻醉组间差异无统计学意义（P = 0.13）。两组患者的血流动力学特征相当，但右美托咪定组插管后和 60 min 时的心率显著降低。右美托咪定组研究药物初始负荷剂量后平均动脉压显著降低。（P<0.05）。结论 右美托咪定在术中使用有显著的镇静效果，右美托咪定是一种简单、有效、安全的方法，可避免术中阴茎勃起，右美托咪定代替丙泊酚用于泌尿系男患者具有显著的疗效和安全性优势，在临床上可以作为泌尿外科手术时患者使用的镇静剂选择。

Abstract

Objective This study investigates and analyzes the efficacy of dexmedetomidine instead of propofol in male patients with urinary system.
Methods The subjects were 100 male patients hospitalized in the Department of Urology of our hospital from January 2024 to December 2024. They were randomly assigned to receive dexmedetomidine group (observation group) and propofol intravenous anesthesia group (control group), 50 people in each group. Midazolam 0.1mg/kg was used to replace propofol for anesthesia induction, and dexmedetomidine 0.4ug/Kg/h was used to replace propofol for anesthesia maintenance. The recovery was evaluated by measuring the heart rate (HR), mean arterial pressure (MAP), and blood oxygen saturation (SpO2) of the two groups of patients before and after anesthesia. The occurrence of penile erection during surgery and the time from the beginning to the end of penile erection were recorded.
Results There was no significant difference between the two groups in total intravenous propofol anesthesia during surgery (P = 0.13). The hemodynamic characteristics of the two groups were comparable, but the heart rate was significantly lower after intubation and at 60 min in the dexmedetomidine group. The mean arterial pressure was significantly reduced after the initial loading dose of the study drug in the dexmedetomidine group. (P<0.05).
Conclusion   Dexmedetomidine has a significant sedative effect when used during surgery. Dexmedetomidine is a simple, effective and safe method that can avoid penile erection during surgery. Dexmedetomidine has significant efficacy and safety advantages when used instead of propofol in male patients with urinary system surgery. It can be used as a sedative for patients during urological surgery in clinical practice.