Expression and significance of Furin in ovarian endometriosis
Furin在卵巢子宫内膜异位症中的表达及意义

摘要

目的 分析将弗林蛋白酶（Furin）应用于卵巢子宫内膜异位症患者的临床诊断中的价值；方法 本次研究采取回顾性研究的形式，选取2022年4月至2024年4月我院接诊的42例子宫内膜异位症患者进行分析，纳为观察组，再选取同期接受检查的42例健康患者作为对照组，对两组的血清Furin、TGF-β及VEGF水平进行比较，以此判断其与子宫内膜异位症病情进展的关系；结果 观察组的血清Furin、TGF-β及VEGF水平均高于对照组（P<0.05）。观察组在基因型CC及TT位点中的基因频率均高于对照组（P<0.05），在等位基因中的C及T位点的基因频率低于对照组（P<0.05）；结论 将Furin应用于卵巢子宫内膜异位症患者的临床诊断中，相较于正常患者血清Furin水平明显上升，并以TT基因型患者的Furin水平升高最显著。

Abstract

Objective To analyze the clinical diagnostic value of Furin in patients with ovarian endometriosis;
Methods This study adopted a retrospective research approach, selecting 42 patients with endometriosis who were admitted to our hospital from April 2022 to April 2024 as the observation group. Then, 42 healthy patients who underwent examinations during the same period were selected as the control group. The serum levels of Furin, TGF - β, and VEGF were compared between the two groups to determine their relationship with the progression of endometriosis;
Results The serum levels of Furin, TGF - β, and VEGF in the observation group were higher than those in the control group (P<0.05). The gene frequencies of genotype CC and TT loci in the observation group were higher than those in the control group (P<0.05), while the gene frequencies of allele C and T loci were lower than those in the control group (P<0.05);
Conclusion   Applying Furin to the clinical diagnosis of ovarian endometriosis patients shows a significant increase in serum Furin levels compared to normal patients, with the most significant increase observed in Furin levels in patients with TT genotype.