[email protected]

国际临床研究杂志

International Journal of Clinical Research

您当前位置：首页 > 精选文章

International Journal of Clinical Research. 2025; 9: (3) ; 10.12208/j.ijcr.20250169 .

Study on the early diagnostic value of serum AFP, CA19-9, CEA combined test for primary liver cancer
血清AFP、CA19-9、CEA联合检验对原发性肝癌的早期诊断价值研究

作者： 罗变红 *

甘肃陇西县第二人民医院 甘肃定西

*通讯作者： 罗变红,单位：甘肃陇西县第二人民医院 甘肃定西；

引用本文: 罗变红 血清AFP、CA19-9、CEA联合检验对原发性肝癌的早期诊断价值研究[J]. 国际临床研究杂志, 2025; 9: (3) : 194-196.
Published: 2025/3/31 13:10:07

摘要

目的 分析血清AFP、CA19-9、CEA联合检验对原发性肝癌的早期诊断价值。方法 选择2023年1-12月于我院确诊的慢性肝炎、肝硬化、原发性肝癌，健康体检者各80例，行血清AFP、CA19-9、CEA检验，对比不同患者标志物检出率、对比血清AFP、CA19-9、CEA联合检验的诊断效能。结果 原发性肝癌血清AFP、CA19-9、CEA联合检出率最高，血清AFP、CA19-9、CEA联合检验的诊断效能高于单一检测，差异有统计学意义（P﹤0.05），结论 血清AFP、CA19-9、CEA联合检验可筛查出原发性肝癌，利于确诊疾病和指导后续治疗。

关键词： 血清AFP；CA19-9；CEA；联合检验；原发性肝癌的早期诊断；癌胚抗原；糖蛋白

Abstract

Objective To analyze the early diagnostic value of serum AFP, CA19-9, CEA combined test for primary liver cancer.
Methods Eighty healthy individuals diagnosed with chronic hepatitis, cirrhosis, and primary liver cancer in our hospital from January to December 2023 were selected for serum AFP, CA19-9, and CEA tests. The detection rates of different patient biomarkers and the diagnostic efficacy of combined serum AFP, CA19-9, and CEA tests were compared.
Results The combined detection rate of serum AFP, CA19-9, and CEA was the highest in primary liver cancer. The diagnostic efficacy of the combined test of serum AFP, CA19-9, and CEA was higher than that of a single test, and the difference was statistically significant (P<0.05).
Conclusion   The combined test of serum AFP, CA19-9, and CEA can screen for primary liver cancer, which is beneficial for diagnosing the disease and guiding subsequent treatment.

Key words： Serum AFP; CA19-9; CEA; Joint inspection; Early diagnosis of primary liver cancer; Carcinoembryonic antigen; Glycoprotein

参考文献 References

[1] 张成芳,陈晓琼,聂新民. 超声造影、CT增强联合肿瘤标志物AFP、CA199诊断肝癌的临床研究[J]. 中国CT和MRI杂志,2024,22(9):100-103. 

[2] 赵梦. DCE--MRI减影技术及DWI在原发性肝癌局部介入术后疗效评估中的应用研究[D]. 山东:山东大学,2020. 

[3] 张立娅,张小彩,王毕仙,等. 肝细胞肝癌CT与MR影像学检查的临床诊断价值比较[J]. 影像研究与医学应用,2024, 8(13):123-125. 

[4] 陈招娣,王盈,游建华,等. 血清AFP、CA19-9、CEA联合检验对原发性肝癌的早期诊断价值研究[J]. 罕少疾病杂志,2024,31(12):81-83. 

[5] 曲茹,李媛媛,周婷. 血清AFP、CA19-9、CEA单项及三者联合检验对原发性肝癌的早期诊断价值[J]. 中国医药指南,2021,19(7):104-105. 

[6] 中华人民共和国国家卫生健康委员会医政司. 原发性肝癌诊疗指南(2024年版)[J]. 磁共振成像,2024,15(6):1-18. 

[7] 徐彤,丁宇,高双全,等. 血清AFP阴性肝癌中EGFR的表达与临床及预后的关系[J]. 肝胆外科杂志,2020,28(5): 356-359.

[8] 甘雨,吴相波,但汉君,等. 术前CA19-9联合FIB含量预测肝癌切除术后早期复发的临床意义[J]. 空军军医大学学报,2024(3):257-262.

[9] 马良. 血清AFP、CA19-9、CEA联合检测在原发性肝癌早期诊断中的应用价值[J]. 临床医学,2022,42(7):82-84.

[10] 钱彩霞,孙强. 血清AFP、CA19-9、CEA单项及三者结合检验对原发性肝癌的早期诊断价值分析[J]. 大健康, 2024(15): 146-148.