International Journal of Clinical Research
International Journal of Clinical Research. 2025; 9: (6) ; 10.12208/j.ijcr.20250278 .
总浏览量: 71
1 吉首大学 湖南吉首
2 益阳市中心医院血管外科 湖南益阳
3 市中心医院内科 湖南益阳
*通讯作者： 谭岁赛,单位： 益阳市中心医院血管外科 湖南益阳；
淋巴水肿是一种因淋巴液回流障碍导致的慢性疾病，发病率呈上升趋势。本文综述其发病机制与治疗进展：原发性淋巴水肿与 VEGFR-3等基因异常有关，继发性淋巴水肿多由手术、放疗、感染等因素引发。治疗方面，保守治疗以综合消肿疗法为主，结合物理技术与新型药物；外科治疗通过 LVA、VLNT等手术重建淋巴通路，干细胞技术展现应用潜力。目前存在早期诊断困难、个体化方案不足等问题，未来需在靶向药物、人工智能诊断等方向深入研究，以推动淋巴水肿诊疗的精准化与高效化。
Lymphedema is a chronic disease caused by the disorder of lymphatic fluid reflux, and its incidence rate is on the rise. This article reviews its pathogenesis and treatment progress: Primary lymphedema is related to gene abnormalities such as VEGFR-3, while secondary lymphedema is mostly caused by factors such as surgery, radiotherapy, and infection. In terms of treatment, conservative treatment mainly focuses on comprehensive swelling reduction therapy, combined with physical techniques and new drugs. Surgical treatment reconstructs lymphatic pathways through surgeries such as LVA and VLNT, and stem cell technology shows its application potential. At present, there are problems such as difficulties in early diagnosis and insufficient individualized plans. In the future, in-depth research is needed in directions such as targeted drugs and artificial intelligence diagnosis to promote the precision and efficiency of lymphedema diagnosis and treatment.
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