Study on synchronous radiotherapy and chemotherapy combined with early comprehensive nutritional therapy in locally advanced nasopharyngeal carcinoma
同步放化疗联合早期综合营养治疗在局部晚期鼻咽癌中的研究

摘要

目的 观察分析对局部晚期鼻咽癌患者实施同步放化疗联合早期综合营养治疗的临床效果和应用价值。方法 选择院内就诊的60例局部晚期鼻咽癌患者（样本纳入例数：60例；样本纳入时间：2023年5月至2024年5月），以随机数字为基础分组方式，分为对照、实验两个小组，观察例数高度一致。分别实施同步放化疗，同步放化疗联合早期综合营养治疗。收集分析治疗效果。结果 与对照组（同步放化疗）相比，实验组（同步放化疗联合早期综合营养治疗）的白蛋白水平、转铁蛋白水平、血红蛋白水平更高，CD3+、CD4+、CD8+*CD28+、CD4+/CD8+更高，生活质量评分（角色功能/情绪功能/认知功能/社会功能/躯体功能/总体健康）更高，差异具有统计学意义（P<0.05）。结论 同步放化疗联合早期综合营养治疗可以有效减少疾病和治疗对局部晚期鼻咽癌患者营养状况的不良影响，有助于促进免疫状况改善，提高生活质量，改善预后，有较高应用价值。

Abstract

Objective Observation and analysis of the clinical efficacy and application value of synchronous radiotherapy and chemotherapy combined with early comprehensive nutritional therapy in patients with locally advanced nasopharyngeal carcinoma.
Methods Sixty patients with locally advanced nasopharyngeal carcinoma who received medical treatment in the hospital were selected (sample included: 60 cases; sample included time: May 2023 to May 2024), and were randomly divided into control and experimental groups based on random numbers. The number of observed cases was highly consistent. Implement synchronous radiotherapy and chemotherapy separately, and combine synchronous radiotherapy and chemotherapy with early comprehensive nutritional therapy. Collect and analyze treatment effects.
Results Compared with the control group (synchronous radiotherapy and chemotherapy), the experimental group (synchronous radiotherapy and chemotherapy combined with early comprehensive nutritional therapy) had higher levels of albumin, transferrin, hemoglobin, CD3+, CD4+, CD8+* CD28+, CD4+/CD8+, and higher quality of life scores (role function/emotional function/cognitive function/social function/physical function/overall health), with statistically significant differences (P<0.05).
Conclusion   Simultaneous chemoradiotherapy combined with early comprehensive nutritional therapy can effectively reduce the adverse effects of disease and treatment on the nutritional status of locally advanced nasopharyngeal carcinoma patients, promote the improvement of immune status, enhance quality of life, improve prognosis, and have high application value.