Clinical comparative study of different doses of nalbuphine combined with lidocaine in propofol based gastrointestinal endoscopy
不同剂量纳布啡复合利多卡因应用于以丙泊酚为基础的消化内镜检查的临床对比研究

摘要

目的 分析不同剂量纳布啡复合利多卡因应用于以丙泊酚为基础的消化内镜检查的临床对比差异。方法 选取2024年3月至2025年1月到医院行无痛消化内镜检查（先做胃镜后做结肠镜）患者当作研究对象，入选对象共300例，依照药物剂量作为分组原则，分为A组（静脉注射纳布啡0.05mg/kg+利多卡因0.5mg/kg）、B组（静脉注射纳布啡0.1mg/kg+利多卡因0.5mg/kg）、C组（静脉注射纳布啡0.5mg/kg）、D组（静脉注射纳布啡0.1mg/kg）、E组（静脉注射利多卡因0.5mg/kg）、F组（静脉注射生理盐水），每组50例。对比六组的丙泊酚引起注射痛严重程度及不良反应发生率。结果 在丙泊酚引起注射痛分级上，B组优于A组、C组、D组、E组、F组（P＜0.05）。在并发症发生率上，B组低于A组、C组、D组、E组、F组（P＜0.05）。结论 0.1mg/kg纳布啡+0.5mg/kg利多卡因用于以丙泊酚为基础的消化内镜检查的效果良好，有助于减轻丙泊酚引起注射疼痛程度，减少不良反应的发，临床可进一步推广应用。

Abstract

Objective To analyze the clinical comparative differences of different doses of nalbuphine combined with lidocaine in propofol based gastrointestinal endoscopy.
Methods A total of 300 patients who underwent painless digestive endoscopy (gastroscopy followed by colonoscopy) at the hospital from March 2024 to January 2025 were selected as the study subjects. According to the principle of drug dosage, they were divided into Group A (intravenous injection of nalbuphine 0.05mg/kg+lidocaine 0.5mg/kg), Group B (intravenous injection of nalbuphine 0.1mg/kg+lidocaine 0.5mg/kg), Group C (intravenous injection of nalbuphine 0.5mg/kg), Group D (intravenous injection of nalbuphine 0.1mg/kg), Group E (intravenous injection of lidocaine 0.5mg/kg), and Group F (intravenous injection of physiological saline), with 50 patients in each group. Compare the severity of injection pain and incidence of adverse reactions caused by propofol in six groups.
Results In terms of pain grading caused by propofol injection, Group B was superior to Group A, C, D, E, and F (P<0.05). In terms of the incidence of complications, Group B was lower than Group A, C, D, E, and F (P<0.05).
Conclusion   The use of 0.1 mg/kg nalbuphine and 0.5 mg/kg lidocaine for propofol based gastrointestinal endoscopy is effective in reducing injection pain caused by propofol and minimizing the occurrence of adverse reactions. It can be further promoted and applied in clinical practice.