The effect of levofloxacin in the treatment of adult patients with Helicobacter pylori (HP) positive and chronic gastritis
左氧氟沙星治疗成人HP阳性合并慢性胃炎的效果

摘要

目的 观察幽门螺杆菌（Hp）阳性合并慢性胃炎患者接受左氧氟沙星治疗的临床效果。方法 本研究将采用随机对照试验研究设计，随机选取82例Hp阳性合并慢性胃炎患者作为研究对象（均为2023年2月至2024年8月在本校校医院接受治疗患者），并按照1:1的比例随机分为两组，即为对照组及观察组，每组41例。其中参考组采取常规四联治疗，观察组在上述基础上应用左氧氟沙星治疗。对比分析两组治疗疗效及不良反应发生率，为临床选择更好的治疗方法，提供科学依据。结果 观察组患者治疗效果明显优于对照组患者（P<0.05）。观察组患者HP感染根除率明显低于对照组患者（P<0.05）。观察组不良反应发生率低于对照组（P<0.05）。结论 将常规四联疗法中的克拉霉素替换为左氧氟沙星可以提高治疗有效率和HP感染根除率，同时降低不良反应发生率。

Abstract

Objective To observe the clinical effect of levofloxacin treatment in patients with Helicobacter pylori (Hp) positive and chronic gastritis.
Methods This study will adopt a randomized controlled trial design. A total of 82 patients with Hp positive and chronic gastritis (all treated at the university hospital from February 2023 to August 2024) were randomly selected and divided into two groups at a ratio of 1:1, namely the control group and the observation group, with 41 cases in each group. The control group received conventional quadruple therapy, while the observation group was treated with levofloxacin on this basis. The therapeutic effects and the incidence of adverse reactions in both groups were compared and analyzed to provide a scientific basis for choosing a better treatment method in clinical practice.
Results The therapeutic effect of the observation group was significantly better than that of the control group (P < 0.05). The Hp eradication rate in the observation group was significantly lower than that in the control group (P < 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P < 0.05).
Conclusion   Replacing clarithromycin with levofloxacin in the conventional quadruple therapy can improve the treatment efficiency and Hp eradication rate, while reducing the incidence of adverse reactions.