Observation on the efficacy of different doses of erythropoietin in the prevention and treatment of anemia in premature infants
不同剂量促红细胞生成素防治早产儿贫血的疗效观察

摘要

目的 探讨分析不同剂量促红细胞生成素（EPO）对早产儿贫血的防治效果。方法 本次研究以对照实验形式进行，选取4组早产儿作为研究对象，每组62例，分别为甲、乙、丙组和对照组，甲、乙、丙3组均接受EPO治疗，剂量分别控制为每周750 IU/kg、450 IU/kg、300 IU/kg，对照组不使用EPO，比较4组早产儿的网织红细胞（RET）、血红蛋白（HB）。结果 治疗前各组早产儿RET指标水平无明显差异（P＞0.05），治疗5周时，甲组RET指标明显高于其他3组（P＜0.05）；治疗前各组早产儿HB指标水平无明显差异（P＞0.05），治疗后各组HB水平均下降，在治疗5周时，甲组HB指标明显高于其他3组（P＜0.05）。结论 对早产儿使用EPO可防治贫血，高剂量用药效果更优。

Abstract

Objective To explore and analyze the effects of different doses of erythropoietin (EPO) on the prevention and treatment of anemia in premature infants.
Methods This study was conducted in the form of a controlled experiment. Four groups of premature infants were selected as the research subjects, with 62 cases in each group, namely group A, group B, group C and control group. Group A, group B and group C all received EPO treatment, and the doses were controlled at 750 IU/kg, 450 IU/kg and 300 IU/kg per week, respectively. The control group did not use EPO. The reticulocytes (RET) and hemoglobin (HB) of the four groups of premature infants were compared.
Results There was no significant difference in the RET index level of premature infants in each group before treatment (P>0.05). At 5 weeks of treatment, the RET index of group A was significantly higher than that of the other three groups (P<0.05). There was no significant difference in the HB index level of premature infants in each group before treatment (P>0.05). After treatment, the HB level of each group decreased. At 5 weeks of treatment, the HB index of group A was significantly higher than that of the other three groups (P<0.05).
Conclusion   The use of EPO in premature infants can prevent and treat anemia, and high-dose medication is more effective.