Observation of the immune effect of hepatitis B vaccination in children
儿童乙型肝炎疫苗接种的免疫效果观察

摘要

目的 本研究旨在观察儿童接种乙型肝炎疫苗后的免疫效果。方法 研究采用前瞻性队列研究设计，选取2022年1月至2023年12月期间，我院儿科预防接种门诊管理的80例儿童随机分为观察组和对照组，每组各40例。观察组接受全程三针乙肝疫苗接种，并辅以个性化护理；对照组仅接受全程三针乙肝疫苗接种。研究的主要观察指标包括抗体滴度、不良反应发生率、免疫成功率及免疫持久性。结果 观察组儿童的抗体滴度高于对照组（P＜0.05），不良反应发生率低于对照组（P＜0.05），免疫成功率及免疫持久性均优于对照组。结论 全程三针乙肝疫苗接种辅以个性化护理能有效提升儿童接种乙型肝炎疫苗后的免疫效果。

Abstract

Objective This study aims to observe the immune effect of children after receiving hepatitis B vaccine.
Methods Using a prospective cohort study design, 80 children managed from January 2022 to December 2.2023 were randomly divided into observation group and control group, with 40 cases in each group. The observation group received three-dose hepatitis B vaccination with personalized care; the control group received three-dose hepatitis B vaccination only. The main observation measures of the study included antibody titer, incidence of adverse reactions, immune success rate, and immune persistence.
Results The antibody titer of children in the observation group was higher than that of the control group (P <0.05), the incidence of adverse reactions was lower than that in the control group (P <0.05), and the immune success rate and immune persistence were better than that of the control group.
Conclusion   The three doses of hepatitis B vaccine with personalized nursing can effectively improve the immune effect of children after hepatitis B vaccine.