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国际临床研究杂志

International Journal of Clinical Research

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International Journal of Clinical Research. 2025; 9: (2) ; 10.12208/j.ijcr.20250084 .

The pathological diagnostic value of AUF1 in radiation-induced skin injury in rats
AUF1在大鼠放射性皮肤损伤中的病理诊断价值

作者： 刘玉兰, 陈仕高, 胡婕 *

成都医学院第二附属医院·核工业四一六医院 四川成都

*通讯作者： 胡婕,单位：成都医学院第二附属医院·核工业四一六医院 四川成都；

引用本文: 刘玉兰, 陈仕高, 胡婕 AUF1在大鼠放射性皮肤损伤中的病理诊断价值[J]. 国际临床研究杂志, 2025; 9: (2) : 97-99.
Published: 2025/2/13 16:22:18

摘要

目的 研究分析AUF1在大鼠放射性皮肤损伤中的病理诊断价值。方法 选取59只大鼠放射性皮肤损伤组织标本和40正常大鼠皮肤损伤组织标本，常规石蜡病理学诊断作为金标准，对比分析免疫组化检查AUF1的表达。结果 放射性皮肤损伤AUF1免疫组化结果显示为阳性49例、阴性10例；正常皮肤损伤组织AUF1表达为：阳性21例、阴性19例。对比差异明显（P＜0.05）。结论 在大鼠放射性皮肤损伤中的病理诊断有着较高的应用价值。

关键词： 放射性皮肤损伤；大鼠；病理诊断

Abstract

Objective To study and analyze the pathological diagnostic value of AUF1 in radiation-induced skin injury in rats.
Methods Fifty-nine radiation-induced skin injury tissue specimens of rats and 40 normal skin injury tissue specimens of rats were selected. Routine paraffin pathological diagnosis was used as the gold standard, and the expression of AUF1 was detected by immunohistochemistry.
Results Immunohistochemical results of AUF1 in radiation-induced skin injury showed that 49 cases were positive and 10 cases were negative. The expression of AUF1 in normal skin lesions was positive in 21 cases and negative in 19 cases. The difference was significant (P < 0.05).
Conclusion   It has a high application value in pathological diagnosis of radiation-induced skin injury in rats.

Key words： Radiation-induced skin injury; Rats; Pathological diagnosis

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