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国际临床研究杂志

International Journal of Clinical Research

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International Journal of Clinical Research. 2025; 9: (2) ; 10.12208/j.ijcr.20250076 .

Advances in accurate and effective detection of human papillomavirus in head and neck squamous cell carcinoma
人乳头瘤病毒在头颈部鳞状细胞癌中精准检测的研究进展

作者： 周思远1,2, 牛文娟2, 张凌楠3, 王文龙2, 马向瑞2 *

1滨州医学院口腔医学院 山东烟台

2滨州医学院附属医院口腔颌面外科 山东滨州

3滨州医学院附属医院口腔正畸科 山东滨州

*通讯作者： 马向瑞,单位：滨州医学院附属医院口腔颌面外科 山东滨州；

引用本文: 周思远, 牛文娟, 张凌楠, 王文龙, 马向瑞 人乳头瘤病毒在头颈部鳞状细胞癌中精准检测的研究进展[J]. 国际临床研究杂志, 2025; 9: (2) : 69-72.
Published: 2025/2/12 11:43:21

摘要

人乳头瘤病毒（human papilloma virus, HPV）持续感染已被公认为是头颈部鳞状细胞癌（head and neck squamous cell carcinoma, HNSCC）的独立致病因素之一，与传统的HNSCC相比，HPV相关HNSCC是一类具有不同分子生物学发病机制及独特临床病理特征的疾病。多项研究证实HPV持续感染是HNSCC良好预后的重要标志物之一。临床上针对HPV精准有效的检测方法具有极其重要的诊疗意义，然而到目前为止还没有一种方法可以作为检测头颈部鳞癌HPV感染的金标准。本文围绕HPV各种检测方法的现状及未来做一综述，以期为临床选择精准快速的HPV检测方法提供参考及借鉴。

关键词： 人乳头瘤病毒；头颈部鳞状细胞癌；精准检测；诊断

Abstract

Persistent infection of human papillomavirus (HPV) has been recognized as an independent pathogenic factor of head and neck squamous cell carcinoma (HNSCC). Compared with traditional HNSCC, HPV-associated HNSCC is a disease with different molecular biological pathogenesis and unique clinicopathological characteristics. Many studies have confirmed that HPV persistent infection is one of the important markers for good prognosis of HNSCC. Accurate and effective detection methods for HPV in clinical practice are of great significance in diagnosis and treatment. However, up to now, no method can be used as the gold standard for detecting HPV infection in head and neck squamous cell carcinoma. This article reviews the current status and future of HPV detection methods, in order to provide reference for clinical selection of accurate and rapid HPV detection methods.

Key words： Human papillomavirus; Head and neck squamous cell carcinoma; Accurate detection; Diagnosis

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