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国际临床研究杂志

International Journal of Clinical Research

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International Journal of Clinical Research. 2025; 9: (5) ; 10.12208/j.ijcr.20250244 .

Application value of combined detection of pepsinogen and gastrin 17 in Hp related chronic non-atrophic gastritis
胃蛋白酶原、胃泌素17联合检测对Hp相关慢性非萎缩性胃炎的应用价值

作者： 张顺玲1, 郑盛2 *, 杨涓2, 刘佩2, 曾雪丽2, 李心怡2

1 大理大学临床医学院 云南大理

2 大理大学第二附属医院（云南省第三人民医院）消化内科 云南昆明

*通讯作者： 郑盛,单位： 大理大学第二附属医院（云南省第三人民医院）消化内科 云南昆明；

引用本文: 张顺玲, 郑盛, 杨涓, 刘佩, 曾雪丽, 李心怡 胃蛋白酶原、胃泌素17联合检测对Hp相关慢性非萎缩性胃炎的应用价值[J]. 国际临床研究杂志, 2025; 9: (5) : 95-99.
Published: 2025/5/29 11:55:57

摘要

目的 探索胃蛋白酶原I（PGI）、胃蛋白酶原II（PGII）、PGI/PGII（PGR）、胃泌素17（G-17）联合检测对Hp相关慢性非萎缩性胃炎的应用价值。方法 选取2024年1月至2024年11月大理大学第二附属医院确诊为慢性非萎缩性胃炎的患者80例，其中合并Hp阳性患者40例为研究组，Hp阴性患者40例为对照组。收集血清学标本，检测PGI、PGII、G-17浓度，并计算PGR。比较2组受试者上述4项指标差异性，用受试者工作曲线评估 PGI、PGII、PGR、G-17在Hp相关慢性非萎缩性胃炎的临床应用价值。结果 Hp阳性慢性非萎缩性胃炎患者PGI（187.99μg/L VS 122.29μg/L，P<0.05）、PGII（9.52μg/L VS 7.32μg/L，P<0.05）、G-17（5.59 pmol/L VS 3.47 pmol/L，P<0.05）高于Hp阴性慢性非萎缩性胃炎患者；PGI、PGII、G-17单独检测诊断Hp感染慢性非萎缩性胃炎的AUC值分别为0.754、0.680、0.649，联合检测AUC值为0.762，联合检测诊断效能较高。结论 血清PGI、PGII、G-17对鉴别慢性非萎缩性胃炎是否合并Hp感染更具临床价值。

关键词： 慢性非萎缩性胃炎；幽门螺杆菌；胃蛋白酶原I；胃蛋白酶原II；胃泌素17

Abstract

Objective To explore the application value of combined detection of pepsinogen I (PGI), pepsinogen II (PGII), PGI/PGII (PGR) and gastrin 17 (G-17) in Hp-related chronic non-atrophic gastritis.
Methods A total of 80 patients diagnosed with chronic non-atrophic gastritis from the Third People's Hospital of Yunnan Province from January 2024 to November 2024 were selected, including 40 Hp-positive patients as the study group and 40 Hp-negative patients as the control group. Serological specimens were collected, PGI, PGII, G-17 concentrations were detected, and PGR was calculated. The differences of the above 4 indexes between the two groups were compared, and the clinical application value of PGI, PGII, PGR and G-17 in Hp-related chronic non-atrophic gastritis was evaluated by subject work curve.
Results In Hp-positive patients with chronic non-atrophic gastritis, PGI (187.99μg/L VS 122.29μg/L，P<0.05),PGII (9.52μg/L VS 7.32μg/L，P<0.05), PG-17 (5.59 pmol/L VS 3.47 pmol/L，P<0.05), higher than Hp-negative chronic non-atrophic gastritis;The AUC values of PGI, PGII and G-17 were 0.754, 0.680 and 0.649, respectively, and the AUC values of combined detection were 0.762, indicating that the combined detection had high diagnostic efficiency.
Conclusion   Serum PGI, PGII and G-17 are more valuable in differentiating chronic non-atrophic gastritis with Hp infection.

Key words： Chronic non-atrophic gastritis; Helicobacter pylori; pepsinogen I; pepsinogen II; gastrin 17

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