International Journal of Clinical Research
International Journal of Clinical Research. 2025; 9: (5) ; 10.12208/j.ijcr.20250238 .
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1 大理大学临床医学院 云南大理
2 大理大学第二附属医院 云南昆明
*通讯作者： 杨涓,单位： 大理大学第二附属医院 云南昆明；
肝癌在我国的发病率居高不下，肝细胞癌（hepatocellular carcinoma，HCC）是肝癌最常见的类型[1]。自噬是一种进化保守的细胞内降解过程，通过将细胞内的大分子、过量或受损的细胞器输送到溶酶体进行降解，从而维持细胞稳态，并为细胞生存提供必要的营养物质和生物分子[2]。肝癌干细胞（Liver cancer stem cells，LCSC）具有自我更新和多向分化的能力，并且通过调节干性、耐药性和血管生成，促进HCC的发生和进展[3]。在本文中，我们讨论了自噬及肝癌干细胞在肝细胞癌发生发展中的研究进展。
The incidence of liver cancer remains alarmingly high in China, with hepatocellular carcinoma (HCC) being the most prevalent histological type[1]. Autophagy is an evolutionarily conserved intracellular degradation process that maintains cellular homeostasis and provides essential nutrients and biomolecules for cell survival by transporting large molecules, excess or damaged organelles within the cell to lysosomes for degradation.[2]. Liver cancer stem cells (LCSCs), characterized by their self-renewal capacity and multilineage differentiation potential, promote HCC development and progression by regulating stemness, chemoresistance, and angiogenesis[3].In this article, we review the emerging roles of autophagy and hepatic cancer stem cells in the pathogenesis and progression of hepatocellular carcinoma.
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