International Journal of Clinical Research
International Journal of Clinical Research. 2025; 9: (4) ; 10.12208/j.ijcr.20250188 .
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1 大理大学临床医学院 云南大理
2 云南省第三人民医院 云南昆明
*通讯作者： 杨红玲,单位： 云南省第三人民医院 云南昆明；
糖尿病心肌病（Diabetic Cardiomyopathy, DCM）是糖尿病常见的并发症之一，以心肌代谢紊乱、纤维化、氧化应激和线粒体功能障碍为特征。近年来，天然药物金钗石斛（Dendrobium nobile）因其多糖和生物碱成分的潜在药理作用受到广泛关注。本文结合近年研究，综述金钗石斛在糖尿病心肌病治疗中的机制及应用进展。通过分析金钗石斛多糖在调节脂质代谢、抗心肌细胞凋亡、抑制炎症反应、抗氧化应激等方面的药理作用，指出其在DCM治疗中的潜力和未来研究方向。
Diabetic cardiomyopathy(DCM), a significant complication of diabetes mellitus, is characterized by myocardial metabolic disturbances, fibrosis, oxidative stress, and mitochondrial dysfunction. In recent years, Dendrobium nobile(DN), a natural medicinal herb, has garnered significant attention for its pharmacological potential attributed to bioactive components such as polysaccharides and alkaloids. This review synthesizes current research progress on the mechanisms and therapeutic applications of DN in DCM management. Specifically, DN polysaccharides(DNP)exhibit multifaceted cardioprotective effects, including ameliorating lipid metabolism dysregulation, suppressing inflammatory cascades, mitigating oxidative damage, and restoring mitochondrial bioenergetics. Additionally, DN-derived alkaloids contributeto glycemic control and myocardial remodeling inhibition. By integrating experimental evidence from preclinical studies, this article highlights recent advances in understanding DN's molecular targets and itstranslational prospects for combating DCM pathogenesis.
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