International Research in Chinese Medicine
International Research in Chinese Medicine. 2024; 4: (4) ; 10.12208/j.ircm.20240060 .
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1 临汾市第三人民医院 山西临汾
2 唐山市健康管理师协会 河北唐山
3 中国营养学会 北京
4 广东药科大学 广东广州
*通讯作者： 侯爱芳,单位： 临汾市第三人民医院 山西临汾；
本研究探讨了葛根、灵芝、枳梖子、五味子、姜黄和女贞子的组合对小鼠酒精性肝损伤的保护作用。研究表明，该药物组合通过显著增强抗氧化能力，有效抵抗氧自由基对肝脏细胞的损伤，加速受损肝细胞的修复与再生的进程。此外，该组合通过提升肝脏的解毒功能，有助于防止酒精引起的进一步肝损伤，从而恢复肝细胞的正常生理功能。动物实验结果显示，该组合具有明显的辅助保护作用，能显著改善肝脏实质的病损。此外，随着中医药提取和制剂技术的不断进步，预期这些药物的纯度和生物可用性将得到进一步提高，增强其对酒精性肝损伤的治疗效果。
This study explores the protective effect of a combination of kudzu root, ganoderma lucidum, mandarin orange, schisandra chinensis, turmeric and ligustrum lucidum on alcohol-induced liver injury in mice. Studies have shown that this drug combination can effectively resist damage to liver cells caused by oxygen free radicals by significantly enhancing antioxidant capacity and accelerating the repair and regeneration process of damaged liver cells. In addition, this combination helps prevent further liver damage caused by alcohol by improving the liver's detoxification function, thus restoring the normal physiological functions of liver cells. Animal experiment results show that this combination has obvious auxiliary protective effects and can significantly improve liver parenchymal lesions. In addition, with the continuous advancement of traditional Chinese medicine extraction and preparation technology, it is expected that the purity and bioavailability of these drugs will be further improved, enhancing their therapeutic effect on alcoholic liver injury.
[1] 曹盼,葛根素药理作用研究新进展[J]中成药,2021.8, 43(8).
[2] 史晨旭,葛根化学成分及药理作用研究进展［J］中国现代中药,2021.12,23(12).
[3] 陈玉胜等,灵芝多糖对CCl4诱导的急性肝损伤小鼠的抗炎和保肝活性[J]食品科学,2017,38(17):210-215.
[4] 王文彤,中药枳梖子药理作用研究[J]天津药学,2011,23 (1): 51-53.
[5] 王珢芸,枳梖子及其复方解酒保肝作用研究进展[J]亚太传统医药,2018.3,14(3):77-79.
[6] 白文宇,五味子化学成分及其药理作用研究进展[J]中成药,2019.9,41(9):2177-2183.
[7] 于纯淼,五味子药理作用研究进展及在保健食品中的应用[J]食品工业,2022,43(11):211-226.
[8] 孙林林,姜黄化学成分及药理作用研究进展[J]山东中医药大学学报,2019.3,43(2):207-211.
[9] 刘亭亭,女贞子化学成分与药理作用研究进展[J]中国实验方剂学杂志,2014.7,20(14):228-234.