Clinical Observation of Shenqi Dihuang Decoction Combined with Dagelin in the Treatment of diabetes Nephropathy
参芪地黄汤联合达格列净治疗糖尿病肾病的临床观察

摘要

目的 观察分析对糖尿病肾病患者实施参芪地黄汤联合达格列净治疗的临床效果和应用价值。方法采用回顾性研究方法，选择院内就诊的60例糖尿病肾病患者（样本纳入例数：60例；样本纳入时间：2023年5月至2024年5月），以随机摸球为基础分组方式，分为对照、实验两个小组，观察例数高度一致。分别实施达格列净治疗，参芪地黄汤联合达格列净治疗。收集分析治疗效果。结果 与对照组（达格列净治疗）相比，实验组（参芪地黄汤联合达格列净治疗）治疗后的血糖指标（空腹血糖/餐后2h血糖/糖化血红蛋白）更低，肾功能指标（血清肌酐/尿酸/胱抑素C）更低，炎症因子指标（白细胞介素6/肿瘤坏死因子α/超敏C反应蛋白）更低，不良反应发生率更低，差异具有统计学意义（P<0.05）。结论 参芪地黄汤联合达格列净治疗可以有效减少糖尿病肾病患者不良反应发生率，缓解症状，抑制炎症反应，提升对血糖的控制效果，促进肾功能恢复，有较高应用价值。

Abstract

Objective To observe and analyze the clinical effect and application value of Shenqi Dihuang Decoction combined with dapagliflozin in the treatment of patients with diabetic nephropathy.
Methods A retrospective study method was used to select 60 patients with diabetic nephropathy who were treated in the hospital (sample inclusion number: 60 cases; sample inclusion time: May 2023 to May 2024). They were divided into two groups, control and experimental, based on the random ball-drawing method, and the number of observation cases was highly consistent. Dapagliflozin treatment and Shenqi Dihuang Decoction combined with dapagliflozin treatment were implemented respectively. The treatment effects were collected and analyzed.
Results Compared with the control group (dapagliflozin treatment), the experimental group (Shenqi Dihuang Decoction combined with dapagliflozin treatment) had lower blood sugar indexes (fasting blood sugar/2h postprandial blood sugar/glycosylated hemoglobin), lower renal function indexes (serum creatinine/uric acid/cystatin C), lower inflammatory factor indexes (interleukin 6/tumor necrosis factor α/high-sensitivity C-reactive protein), and lower incidence of adverse reactions after treatment, and the differences were statistically significant (P<0.05).
Conclusion   Shenqi Dihuang Decoction combined with dapagliflozin treatment can effectively reduce the incidence of adverse reactions in patients with diabetic nephropathy, relieve symptoms, inhibit inflammatory response, improve blood sugar control, and promote renal function recovery, and has a high application value.