The effect of combination therapy of irbesartan and nitroprusside on heart rate and endothelial function in patients with hypertension and heart failure
厄贝沙坦与硝普钠联合治疗高血压合并心衰对患者心率和血管内皮功能的影响

摘要

目的 分析高血压合并心衰患者采取厄贝沙坦联合硝普钠的治疗效果。方法 本次研究对象为56例高血压合并心衰患者，抽取时间为2022年1月-2023年1月期间。以随机数字表法分为参考组及实验组，每组28例，其中参考组采取硝普钠治疗，实验组在上述基础上采取厄贝沙坦治疗。对比两组治疗效果。结果 治疗前两组血压及心率指标对比差异小（P＞0.05），治疗后实验组均低于参考组（P＜0.05）。实验组内皮功能优于参考组（P＜0.05）。结论 高血压合并心衰患者采取厄贝沙坦联合硝普钠的治疗可获得显著的治疗效果，能够显著改善患者的血压、心率指标及内皮功能，此种方法值得推广于临床。

Abstract

Objective To analyze the therapeutic effect of irbesartan combined with nitroprusside in patients with hypertension and heart failure.
Methods The subjects of this study were 56 patients with hypertension and heart failure, and the sampling period was from January 2022 to January 2023. Divided into a reference group and an experimental group using a random number table method, with 28 cases in each group. The reference group received treatment with nitroprusside, while the experimental group received treatment with irbesartan based on the above. Compare the therapeutic effects of two groups.
Results The difference in blood pressure and heart rate indicators between the two groups before treatment was small (P>0.05), and after treatment, the experimental group was lower than the reference group (P<0.05). The endothelial function of the experimental group was better than that of the reference group (P<0.05).
Conclusion   The combination of irbesartan and nitroprusside can achieve significant therapeutic effects in patients with hypertension and heart failure, and can significantly improve their blood pressure, heart rate indicators, and endothelial function. This method is worth promoting in clinical practice.