Clinical study on the combination of Shuangge Jiejiu Formula and Naloxone Hydrochloride Injection in the treatment of non comatose patients with acute alcohol poisoning
双葛解酒方联合盐酸纳洛酮注射液治疗急性酒精中毒非昏迷期患者临床研究

摘要

目的 分析在急性酒精中毒非昏迷期患者的治疗中应用双葛解酒方联合盐酸纳洛酮注射液的治疗价值。方法 将2022年1月-2023年12月急诊科就诊急性酒精中毒非昏迷期患者102例以随机分51例对照组盐酸纳洛酮注射液治疗，另51例观察组增加双葛解酒方治疗，对比治疗价值。结果 治疗1h 、6h，观察组呼气酒精浓度更低，且急性肝损伤、消化道出血发生率低于对照组，酒精完全代谢时间、整体住院时间优于对照组，对比有统计学意义（P﹤0.05）。结论 双葛解酒方联合盐酸纳洛酮注射液治疗急性酒精中毒非昏迷期患者可加速酒精代谢、缓解肝脏和消化道压力，降低并发症，促进尽早转归。

Abstract

Objective To analyze the therapeutic value of using Shuangge Jiejiu Formula combined with naloxone hydrochloride injection in the treatment of non comatose patients with acute alcohol poisoning.
Methods 102 non comatose patients with acute alcohol poisoning who visited the emergency department from January 2022 to December 2023 were randomly divided into a control group (n=51) treated with naloxone hydrochloride injection, and an observation group (n=51) treated with Shuangge Jiejiu formula. The therapeutic value was compared.
Results After 1 hour and 6 hours of treatment, the observation group had lower exhaled alcohol concentration, and the incidence of acute liver injury and digestive bleeding was lower than that of the control group. The complete alcohol metabolism time and overall hospitalization time were better than those of the control group, and the comparison was statistically significant (P<0.05).
Conclusion   The combination of Shuangge Jiejiu Formula and Naloxone Hydrochloride Injection can accelerate alcohol metabolism, relieve liver and digestive tract pressure, reduce complications, and promote early recovery in non comatose patients with acute alcohol poisoning.