Analysis of clinical characteristics of patients with chronic obstructive pulmonary disease and obstructive sleep apnea under portable sleep respiratory monitoring
便携式睡眠呼吸监测下慢性阻塞性肺疾病合并阻塞性睡眠呼吸暂停患者的临床特点分析

摘要

目的 分析COPD合并OSA患者的临床特点。方法 选取我院2022-04月-1日至2024-03-31期间收治的100例慢性阻塞性肺疾病合并阻塞性睡眠呼吸暂停患者（观察组）及100例慢性阻塞性肺疾病患者（对照组）为研究对象，以便携式睡眠监测仪监测不同患者的呼吸数据（SLT、RDI、LAT、AHI）、血氧分布（meanSaO2、miniSaO2、TS90%）、肺功能（FEV1%、FEV1/FVC）以及动脉血气指标（pH值、 PO2、 PCO2）。结果 与对照组相比，观察组的睡眠潜伏期较短、呼吸紊乱出现较频繁、LAT值较高、AHI值较高、meanSaO2与miniSaO2值明显更低、TS90%值更高、FEV1%及FEV1/FVC值更低、PO2与pH值更低、PCO2更高，且上述对比有统计学差异（P＜0.05）。结论 与单纯COPD患者相比，COPD合并OSA患者具有睡眠质量问题更突出、低氧血症症状较重以及肺功能较差的临床特点。

Abstract

Objective To analyze the clinical characteristics of patients with COPD and OSA.
Methods 100 patients with chronic obstructive pulmonary disease and obstructive sleep apnea (observation group) and 100 patients with chronic obstructive pulmonary disease (control group) admitted to our hospital from April 1, 2022 to March 31, 2024 were selected as the research subjects. The respiratory data (SLT, RDI, LAT, AHI), blood oxygen distribution (meanSaO2, miniSaO2, TS90%), lung function (FEV1%, FEV1/FVC) and arterial blood gas indexes (pH, PO2, PCO2) of different patients were monitored by portable sleep monitoring.
Results Compared with the control group, the observation group had a shorter sleep latency, more frequent respiratory disorders, higher LAT values, higher AHI values, significantly lower meanSaO2 and miniSaO2 values, higher TS90% values, lower FEV1% and FEV1/FVC values, lower PO2 and pH values, and higher PCO2, and the above comparisons were statistically significant (P < 0.05).
Conclusion   Compared with patients with simple COPD, patients with COPD and OSA have more prominent sleep quality problems, more severe hypoxemia symptoms, and poorer lung function.