International Journal of Clinical Research
International Journal of Clinical Research. 2024; 8: (12) ; 10.12208/j.ijcr.20240516 .
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1 榆林市第一医院内分泌科 陕西榆林
2 延安大学医学院 陕西延安
3 榆林市第一医院新生儿科 陕西榆林
4 榆林市第一医院超声科 陕西榆林
*通讯作者： 贾爱华,单位： 榆林市第一医院内分泌科 陕西榆林；
目的 探讨NICU患儿患有新生儿肺炎、新生儿高胆红素血症对甲状腺功能的影响。方法 根据不同病种分为新生儿肺炎组、新生儿高胆红素血症组，新生儿肺炎组又分为新生儿肺炎不合并呼吸窘迫组和新生儿肺炎合并呼吸窘迫组，比较不同病种甲状腺功能。结果 新生儿肺炎合并呼吸窘迫组FT4、FT3水平低于新生儿肺炎不合并呼吸窘迫组和新生儿高胆红素血症组，差异有显著性（P <0.001)；三组疾病在促甲状腺素水平上比较不存在显著差异（P >0.05)。而三组疾病合并轻度和重度先天性亚临床甲状腺功能减退，差异无统计性意义（P >0.05)。结论 新生儿肺炎不合并呼吸窘迫、新生儿肺炎合并呼吸窘迫、新生儿高胆红素血症中，随着病情加重，FT4、FT3呈下降趋势。NICU中新生儿存在以上疾病可能会影像新生儿甲状腺功能的监测，应及时监测甲状腺功能指导治疗。
Objective To explore the impact of neonatal pneumonia and neonatal hyperbilirubinemia on thyroid function in NICU children. Methods According to different disease types, the patients were divided into neonatal pneumonia group and neonatal hyperbilirubinemia group. The neonatal pneumonia group was further divided into neonatal pneumonia without respiratory distress group and neonatal pneumonia with respiratory distress group. Different disease types were compared. Thyroid function. Results The levels of FT4 and FT3 in the neonatal pneumonia combined with respiratory distress group were lower than those in the neonatal pneumonia without respiratory distress group and the neonatal hyperbilirubinemia group, and the difference was significant (P <0.001); the three groups of diseases had higher thyroid-stimulating effects. There was no significant difference in protein levels (P >0.05). However, the three groups of diseases were combined with mild and severe congenital subclinical hypothyroidism, and the difference was not statistically significant (P >0.05). Conclusion In neonatal pneumonia without respiratory distress, neonatal pneumonia with respiratory distress, and neonatal hyperbilirubinemia, FT4 and FT3 show a downward trend as the condition worsens. The presence of the above diseases in neonates in the NICU may affect the monitoring of neonatal thyroid function, and thyroid function should be monitored in a timely manner to guide treatment.
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