Analysis of the therapeutic effect of phentolamine combined with tranexamic acid in the treatment of pulmonary tuberculosis with hemoptysis
酚妥拉明联合氨甲环酸在肺结核合并咯血治疗中的疗效研究分析

摘要

目的 分析酚妥拉明联合氨甲环酸在肺结核合并咯血病症的疗效评估。方法 选取2022年1月至2023年12月期间，在我院接受治疗的60例肺结核合并咯血病例作为研究样本，随后通过随机分为对照组（30例，采取氨甲环酸治疗）和观察组（30例，采取酚妥拉明联合氨甲环酸治疗），比较两组的临床治疗效果。结果 观察组的动脉血氧分压更高、二氧化碳分压更低（P＜0.05），肺功能指标FEV1、FVC均更优（P＜0.05）。观察组炎症指标与咯血总量均更低（P＜0.05），且症状改善时间更短（P＜0.05）。观察组与对照组的不良反应发生率统计结果显示两者之间并未展现出显著的统计学差异（P＞0.05）。结论 针对肺结核合并咯血患者，采用酚妥拉明与氨甲环酸的联合治疗方案，取得了显著的临床疗效。值得推广与应用。

Abstract

Objective Analysis of the efficacy evaluation of phentolamine combined with tranexamic acid in the treatment of pulmonary tuberculosis with hemoptysis.
Methods Sixty cases of pulmonary tuberculosis complicated with hemoptysis treated in our hospital from January 2022 to December 2023 were selected as the research sample. They were then randomly divided into a control group (30 cases, treated with tranexamic acid) and an observation group (30 cases, treated with phentolamine combined with tranexamic acid) to compare the clinical treatment effects of the two groups.
Results The observation group had higher arterial oxygen partial pressure and lower carbon dioxide partial pressure (P<0.05), and better lung function indicators FEV1 and FVC (P<0.05). The inflammatory indicators and total hemoptysis in the observation group were lower (P<0.05), and the symptom improvement time was shorter (P<0.05). The statistical results of the incidence of adverse reactions between the observation group and the control group showed no significant statistical difference (P>0.05).
Conclusion   The combination therapy of phentolamine and tranexamic acid has achieved significant clinical efficacy for patients with pulmonary tuberculosis complicated with hemoptysis. Worth promoting and applying.