International Research in Chinese Medicine
International Research in Chinese Medicine. 2024; 4: (4) ; 10.12208/j.ircm.20240058 .
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1 南京中医药大学附属苏州市中医医院 江苏苏州
2 苏州市吴门医派研究院 江苏苏州
*通讯作者： 陈江,单位： 南京中医药大学附属苏州市中医医院 江苏苏州 苏州市吴门医派研究院 江苏苏州；
目的 基于湿邪致病理论观察辛通清化法之加味薏苡附子败酱散治疗轻-中度溃疡性结肠炎的临床疗效。方法 将2022年09月至2024年11月于苏州市中医医院及苏州大学附属第二医院治疗46例轻、中度溃疡性结肠炎患者，按照随机数字法分为2组，对照组23例以美沙拉嗪缓释颗粒口服，治疗组23例在对照组的基础上予加味薏苡附子败酱散（汤剂）口服，2组疗程均为12周。对比两组患者治疗前后的中医证候积分、疾病活动指数、结肠镜下的肠黏膜组织学评分，并分析临床疗效。结果 治疗12周后，两组中医证候积分、疾病活动指数、结肠镜下的肠黏膜组织学评分均改善，且治疗组优于对照组，差异有统计学意义（P＜0.05）。结论 加味薏苡附子败酱散结合美沙拉嗪可有效缓解溃疡性结肠炎患者的临床症状，降低炎症反应，促进肠黏膜的愈合，提高生活质量。因此，以“辛通清化法”立论的加味薏苡附子败酱散（代表方）符合UC病机病证。
Objective Based on the theory of pathogenic dampness, the clinical efficacy of modified Yiyi Fuzi Baijiang Powder in the treatment of mild to moderate ulcerative colitis was observed. Methods From September 2022 to November 2024,46 patients with mild to moderate ulcerative colitis were treated in Suzhou Hospital of Traditional Chinese Medicine and the Second Affiliated Hospital of Soochow University. According to the random number method, they were divided into two groups.23 patients in the control group were treated with mesalazine sustained-release granules orally, and 23 patients in the treatment group were treated with modified Yiyi Fuzi Baijiang powder (decoction) orally on the basis of the control group. The course of treatment in both groups was 12 weeks. The TCM syndrome score, disease activity index and histological score of intestinal mucosa under colonoscopy were compared between the two groups before and after treatment, and the clinical efficacy was analyzed. Results After 12 weeks of treatment, the scores of TCM syndromes, disease activity index and histological scores of intestinal mucosa under colonoscopy were improved in both groups, and the treatment group was better than the control group, the difference was statistically significant (P < 0.05). Conclusion Modified Yiyi Fuzi Baijiang Powder combined with mesalazine can effectively alleviate the clinical symptoms of patients with ulcerative colitis, reduce the inflammatory response, promote the healing of intestinal mucosa, and improve the quality of life. Therefore, the modified Yiyi Fuzi Baijiang powder (representative prescription) based on the ' Xintong Qinghua method ' is in line with the pathogenesis of UC.
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