Journal of Microbiology and Immunology
Journal of Microbiology and Immunology. 2024; 1: (1) ; 10.12208/j.jmi.20240003 .
总浏览量: 330
湖南农业大学 湖南长沙
*通讯作者： Cong Li,单位：湖南农业大学 湖南长沙；
肠道菌群作为人体内重要的微环境，与肿瘤的发生发展密切相关。本文就肠道菌群对肿瘤发展的影响进行深入探讨，旨在为理解肿瘤发生发展的机制及寻找新的肿瘤治疗方法提供基础。肠道菌群通过多种机制影响肿瘤发展，包括免疫调节、代谢产物的作用以及直接刺激肿瘤细胞等。肠道菌群中不同种类和数量的细菌对肿瘤发展的影响不同，有益菌群、条件致病菌群和致病菌群均对人体肿瘤有影响。此外，肠道菌群的代谢产物和致癌物也与肿瘤发展密切相关。本文综述了肠道菌群与肿瘤的促癌、致癌关系，以及目前已知的一些肠道菌群影响肿瘤发展的机制。研究肠道菌群对肿瘤发展的影响对于深入了解肿瘤发生、发展的机制、寻找新的肿瘤治疗方法具有重要意义。
Intestinal flora, as an important microenvironment in the human body, is closely linked to tumour development. In this paper, the influence of intestinal flora on tumour development is discussed in depth, aiming to provide a basis for understanding the mechanisms of tumour occurrence and development as well as finding new tumour therapies. Intestinal flora affects tumour development through a variety of mechanisms, including immune regulation, the action of metabolites, and direct stimulation of tumour cells. Different species and numbers of bacteria in the intestinal flora have different effects on tumour development, with beneficial, conditionally pathogenic, and pathogenic flora all having an impact on human tumours. In addition, metabolites and carcinogens of intestinal flora are also closely related to tumour development. This paper reviews the pro- and oncogenic relationships between intestinal flora and tumours, as well as some of the currently known mechanisms by which intestinal flora influence tumour development. The study of the influence of intestinal flora on tumour development is of great significance for an in-depth understanding of the mechanisms of tumour genesis and development, as well as the search for new tumour therapies.
[1] Park EM, Chelvanambi M, Bhutiani N, Kroemer G, Zitvogel L, Wargo JA. Targeting the gut and tumor microbiota in cancer. Nat Med. 2022 Apr; 28(4):690-703.
[2] Ramírez-Labrada AG, Isla D, Artal A, Arias M, Rezusta A, Pardo J, Gálvez EM. The Influence of Lung Microbiota on Lung Carcinogenesis, Immunity, and Immunotherapy. Trends Cancer. 2020 Feb; 6(2):86-97.
[3] Tojo R, Suárez A, Clemente MG, de los Reyes-Gavilán CG, Margolles A, Gueimonde M, Ruas-Madiedo P. Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis. World J Gastroenterol. 2014 Nov 7; 20(41):15163-76.
[4] Leimbach A, Hacker J, Dobrindt U. E. coli as an all-rounder: the thin line between commensalism and pathogenicity. Curr Top Microbiol Immunol. 2013; 358. 3-32.
[5] Pedrolli DB, Ribeiro NV, Squizato PN, de Jesus VN, Cozetto DA; Team AQA Unesp at iGEM 2017. Engineering Microbial Living Therapeutics: The Synthetic Biology Toolbox. Trends Biotechnol. 2019 Jan; 37(1):100-115.
[6] Wong SH, Zhao L, Zhang X, Nakatsu G, Han J, Xu W, Xiao X, Kwong TNY, Tsoi H, Wu WKK, Zeng B, Chan FKL, Sung JJY, Wei H, Yu J. Gavage of Fecal Samples from Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice. Gastroenterology. 2017 Dec; 153(6):1621-1633.e6.
[7] Si H, Yang Q, Hu H, et al. Colorectal cancer occurrence and treatment based on changes in intestinal flora [J]. Seminars in Cancer Biology. 2020, 7013-10.
[8] Alhinai EA, Walton GE, Commane DM. The Role of the Gut Microbiota in Colorectal Cancer Causation. Int J Mol Sci. 2019 Oct 24; 20(21):5295.
[9] Verbeke KA, Boobis AR, Chiodini A, Edwards CA, Franck A, Kleerebezem M, Nauta A, Raes J, van Tol EA, Tuohy KM. Towards microbial fermentation metabolites as markers for health benefits of prebiotics. Nutr Res Rev. 2015 Jun; 28(1):42-66.
[10] Hughes, R., Magee, E.A., Bingham, S. Protein degradation in the large intestine: relevance to colorectal cancer. Curr. Issues Intest. Microbiol. 2000, 1, 51-51. 1, 51-58.
[11] Blachier, F., Mariotti, F., Huneau, J.F., Tome, D. Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences. Amino Acids. 2007, 33, 547-562.
[12] Tan Q, Orsso CE, Deehan EC, Kung JY, Tun HM, Wine E, Madsen KL, Zwaigenbaum L, Haqq AM. Probiotics, prebiotics, synbiotics, and fecal microbiota transplantation in the treatment of behavioural symptoms of autism spectrum disorder: a systematic review. Autism Res. 2021 Sep; 14(9):1820-1836.
[13] Settanni CR, Bibbò S, Ianiro G, Rinninella E, Cintoni M, Mele MC, Cammarota G, Gasbarrini A. Gastrointestinal involvement of autism spectrum disorder. Focus on gut microbiota. Expert Rev Gastroenterol Hepatol. 2021 Jun; 15(6):599-622.
[14] D'Amelio P, Sassi F. Gut Microbiota, Immune System, and Bone. Calcif Tissue Int. 2018 Apr; 102(4):415-425.
[15] Eusebi LH, Zagari RM, Bazzoli F. Epidemiology of Helicobacter pylori infection. Helicobacter. 2014 Sep;19 Suppl 1:1-5.
[16] Camilo V, Sugiyama T, Touati E. Pathogenesis of Helicobacter pylori infection. Helicobacter. 2017 Sep; 22 Suppl 1.
[17] Xusheng Z, Dou Y, Di W, et al. Tissue-resident Lachnospiraceae family bacteria protect against colorectal carcinogenesis by promoting tumor immune surveillance [J]. Cell Host Microbe. 2023, 31(3):418-432.e8.
[18] Mou Y, Du Y, Zhou L, Yue J, Hu X, Liu Y, Chen S, Lin X, Zhang G, Xiao H, Dong B. Gut Microbiota Interact with the Brain Through Systemic Chronic Inflammation. Implications on Neuroinflammation, Neurodegeneration, and Aging. Front Immunol. 2022 Apr 7; 13:796288.
[19] Chen X, Wei J, Zhang Y, Zhang Y, Zhang T. Crosstalk between gut microbiome and neuroinflammation in pathogenesis of HIV-associated neurocognitive disorder. J Neurol Sci. 2024 Jan 18; 457:122889.
[20] Clay SL, Fonseca-Pereira D, Garrett WS. Colorectal cancer: the facts in the case of the microbiota. J Clin Invest. 2022 Feb 15; 132(4):e155101.
[21] Chrysostomou D, Roberts LA, Marchesi JR, Kinross JM. Gut Microbiota Modulation of Efficacy and Toxicity of Cancer Chemotherapy and Immunotherapy. Gastroenterology. 2023 Feb; 164(2):198-213.
[22] Si H, Yang Q, Hu H, et al. Colorectal cancer occurrence and treatment based on changes in intestinal flora [J]. Seminars in Cancer Biology. 2020, 7013-10.
[23] Vargo D, Moskovitz M, Floch MH. Faecal bacterial flora in cancer of the colon. gut. 1980 Aug; 21(8):701-5.
[24] Haoyan C, Tianying T, Shiyuan L, et al. Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumourigenesis [J]. Cell metabolism. 2023, 35(4).
[25] Al-Khazaleh AK, Jaye K, Chang D, Münch GW, Bhuyan DJ. Buds and Bugs: A Fascinating Tale of Gut Microbiota and Cannabis in the Fight against Cancer. Int J Mol. Sci. 2024 Jan 10; 25(2):872.
[26] Ningning L, Chengxiang Y, Luqi W, et al. The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells [J]. Cancer Cell. 2023, 41(11):1927-1944.e9.
[27] Reddy BS, Weisburger JH, Narisawa T, Wynder EL. Colon carcinogenesis in germ-free rats with 1,2-dimethylhydrazine and N-methyl-n'- nitro-Nnitroso-guanidine. Cancer Res. (1974) 34(9):2368-72.
[28] Reddy BS, Narisawa T, Wright P, Vukusich D, Weisburger JH, Wynder EL. Colon carcinogenesis with azoxymethane and dimethylhydrazine in germfree rats. Cancer Res. (1975) 35(2):287-90.
[29] Reddy BS, Narisawa T, Weisburger JH. Colon carcinogenesis in germ-free rats with intrarectal 1,2-dimethylhydrazine and subcutaneous azoxymethane. Cancer Res. (1976) 36(8):2874-6.
[30] Cheng Y, Ling Z, Li L. The Intestinal Microbiota and Colorectal Cancer. Front Immunol. 2020 Nov 30; 11:615056.
[31] Gou H, Su H, Liu D, Wong CC, Shang H, Fang Y, Zeng X, Chen H, Li Y, Huang Z, Fan M, Wei C, Wang X, Zhang X, Li X, and Yu J. Traditional Medicine Pien Tze Huang Suppresses Colorectal Tumorigenesis Through Restoring Gut Microbiota and Metabolites. Gastroenterology. 2023 Dec; 165(6):1404-1419.