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国际临床研究杂志

International Journal of Clinical Research

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International Journal of Clinical Research. 2024; 8: (9) ; 10.12208/j.ijcr.20240371 .

Study on the combination of butylphthalein soft capsules and edaravone in the treatment of acute cerebral infarction
丁苯酞软胶囊联合依达拉奉治疗急性脑梗死的研究

作者: 尚晓艺 *, 何丽影

辽源市中医院 吉林辽源

*通讯作者: 尚晓艺,单位:辽源市中医院 吉林辽源;

引用本文: 尚晓艺, 何丽影 丁苯酞软胶囊联合依达拉奉治疗急性脑梗死的研究[J]. 国际临床研究杂志, 2024; 8: (9) : 130-132.
Published: 2024/9/28 11:26:44

摘要

目的 分析丁苯酞软胶囊联合依达拉奉治疗急性脑梗死的研究。方法 选择本院于2023年1月-2024年1月期间收治的100例急性脑梗死患者为研究对象,将其按随机分组方法分为对照组(50例,采取丁苯酞软胶囊治疗)和观察组(50例,在对照组治疗基础上加用依达拉奉治疗),对两组的临床治疗效果,如两组患者的神经功能(NIHSS)评分、生活质量(生理功能、心理功能、运动功能)评分、日常生活能力(ADL)评分及血清神经元特异性烯醇化酶、超氧化物歧化酶、一氧化氮浓度进行对比与评估。结果 观察组患者的神经功能显著低于对照组(P<0.05)。观察组患者的生理功能、心理功能、运动功能评分均高于对照组(P<0.05)。观察组患者的日常生活能力评分高于对照组(P<0.05)。观察组患者的血清神经元特异性烯醇化酶、超氧化物歧化酶、一氧化氮浓度均优于对照组(P<0.05)。结论 对急性脑梗死患者实施丁苯酞软胶囊联合依达拉奉治疗可取得明显的效果,能够显著改善患者的神经功能。提高生活质量和日常生活能力。有较高应用价值,值得临床工作中推广与应用。

关键词: 丁苯酞软胶囊;依达拉奉;急性脑梗死;神经功能

Abstract

Objective: Study on the treatment of acute cerebral infarction with the combination of butylphthalein soft capsules and edaravone.
Methods: Selecting 100 patients with acute cerebral infarction admitted to our hospital from January 2023 to January 2024 as the research subjects, they were randomly divided into a control group (50 cases, treated with butylphthalein soft capsules) and an observation group (50 cases, treated with edaravone in addition to the control group). The clinical treatment effects of the two groups, such as the neurological function (NIHSS) score, quality of life (physiological function, psychological function, motor function) score, daily living ability (ADL) score, and serum neuron specific enolase, superoxide dismutase, and nitric oxide concentration, were compared and evaluated.
Results: The neurological function of the observation group patients was significantly lower than that of the control group (P<0.05). The physiological, psychological, and motor function scores of the observation group patients were higher than those of the control group (P<0.05). The daily living ability score of the observation group patients was higher than that of the control group (P<0.05). The serum concentrations of neuron specific enolase, superoxide dismutase, and nitric oxide in the observation group were higher than those in the control group (P<0.05).
Conclusion  : The combination of ibuprofen soft capsules and edaravone can achieve significant results in the treatment of acute cerebral infarction patients, and can significantly improve their neurological function. Improve the quality of life and daily living abilities. It has high application value and is worth promoting and applying in clinical work.

Key words: Butylphthalide soft capsules; Edaravone; Acute cerebral infarction; Neurological function

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