International Journal of Clinical Research
International Journal of Clinical Research. 2024; 8: (10) ; 10.12208/j.ijcr.20240402 .
总浏览量: 485
山东省临沂市兰陵县人民医院皮肤科 山东临沂
*通讯作者: 唐真真,单位:山东省临沂市兰陵县人民医院皮肤科 山东临沂;
男性,76 岁,全身丘疹,声音嘶哑 8 年余。皮肤科检查:双侧眼睑增厚,睑缘可见串珠状丘疹,鼻尖、口周、颈部有密集的淡黄色粟粒状丘疹和结节,舌头肥大。组织病理学检查显示:表皮萎缩变薄,真皮全层和皮下脂肪层有大量均质的嗜酸性物质,PAS染色阳性。临床和组织病理学检查证实了LP的诊断。
A 76-year-old male presented with generalized papules involving the entire body, and had hoarseness of voice for more than 8 years. Dermatology examination revealed thickened double eyelids with beaded papules observed on the eyelids, densely yellowish miliary-sized papules and nodules on the tip of the nose, around the mouth, and neck, and the tongue is hypertrophic. Histopathological examination showed: The epidermis shrinks and thins, and there is a large amount of homogeneous eosinophilic substance in the entire dermis and subcutaneous fat layer, The material was positive for PAS. Clinical and histological examination confirmed the diagnosis of LP.
[1] Bhattacharjee R, Chatterjee D, Vinay K. Lipoid Proteinosis. JAMA Dermatol. 2018 Dec 1;154(12):1479-1480.
[2] Sriwastava S, Desai A, Yuliati A, et al. A Child With a Hoarse Cry and Intracranial Calcification. Pediatr Neurol. 2018 Oct;87:78-79.
[3] Sabater-Abad J, Matellanes-Palacios M, Pont-Sanjuan V, et al. Oral Ulcer-A Disabling Manifestation in a Patient With Lipoid Proteinosis. JAMA Dermatol. 2019 Aug 1;155(8):977-979.
[4] Aksoy M, An I. Evaluation of inflammatory parameters in lipoid proteinosis patients. Dermatol Ther. 2020 Nov;33(6): e14495.
[5] Parmar NV, Krishna CV, De D, et al. Papules, pock-like scars, and hoarseness of voice: lipoid proteinosis. Indian J Dermatol Venereol Leprol. 2013;79(1):136
[6] Zhu T, Bai X, Ma D, et al. Identification of a novel three-nucleotide duplication in ECM1 in Chinese siblings affected with lipoid proteinosis. Clin Chim Acta. 2021 Jan; 512:122-126.
[7] Len Chan,Noritaka Oyama, Andrew P South, et al .Rapid diagnosis of lipoid proteinosis using an anti-extracellular matrix protein 1 (ECM1) antibody[J]. Dermatol sci ,2004,35(2):151-153
[8] 耿雯瑾,曹灿,陈凤娟,等.类脂蛋白沉积症[J].临床皮肤科杂志,2021,50(05):285-287.
[9] Kutlu Ö, Ekşioğlu HM. The role of systemic steroids in oral ulcers associated with lipoid proteinosis. Dermatol Ther. 2021 Jan;34(1):e14582.
[10] Rao AG, Koppada D. Lipoid proteinosis. Indian J Dermatol Venereol Leprol. 2015;81(5):549.