The effect of amlodipine combined with valsartan on adverse reactions in community hypertensive patients
氨氯地平联合缬沙坦对社区高血压患者不良反应的影响

摘要

目的 分析氨氯地平联合缬沙坦对社区高血压患者不良反应的影响。方法 选择我站于2023年3月-2024年4月内收治的高血压患者80例为研究对象，将其按随机分组方法分为对照组（50例，采取缬沙坦治疗）和观察组（50例，采取氨氯地平联合缬沙坦治疗），对两组患者的临床治疗效果，如患者的血压水平（收缩压、舒张压）、动脉粥样硬化指标、血液粘稠度指标以及不良反应发生率（眩晕、头痛、心率加快）进行对比与评估。结果 两组患者在治疗后均取得一定效果，观察组患者的收缩压与舒张压水平均低于对照组（P＜0.05）。观察组患者的不良反应发生率低于对照组（P＜0.05）。观察组患者的动脉粥样硬化指标和血液粘稠度指标水平均低于对照组（P＜0.05）。结论 在对社区高血压患者实施氨氯地平联合缬沙坦治疗可取得明显效果，血压控制效果显著，降低不良反应发生率。在实际应用中展现出较高的价值，值得临床推广使用。

Abstract

Objective: Analyze the effect of amlodipine combined with valsartan on adverse reactions in community hypertensive patients.
Methods: 80 patients with hypertension who were admitted to our station from March 2023 to April 2024 were selected as the research objects. They were randomly divided into the control group (50 patients, treated with valsartan) and the observation group (50 patients, treated with amlodipine combined with valsartan). The clinical treatment effects of the two groups of patients, such as blood pressure level (systolic pressure, diastolic pressure), atherosclerosis indicators, blood viscosity indicators and the incidence of adverse reactions (dizziness, headache, heart rate acceleration), were compared and evaluated.
Results: Both groups of patients achieved certain results after treatment, and the average systolic and diastolic blood pressure of the observation group was lower than that of the control group (P<0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05). The levels of atherosclerosis and blood viscosity in the observation group were lower than those in the control group (P<0.05).
Conclusion  : The implementation of amlodipine combined with valsartan in the treatment of hypertension patients in the community can achieve significant results, significantly improve patients' blood lipid levels, significantly control blood pressure, and reduce the incidence of adverse reactions. It has demonstrated high value in practical applications and is worthy of clinical promotion and use.