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国际临床研究杂志

International Journal of Clinical Research

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International Journal of Clinical Research. 2024; 8: (8) ; 10.12208/j.ijcr.20240285 .

Deciphering the role for magnesium in cardiovascular diseases
镁在人类心血管疾病中的作用

作者: 罗宇琦1, 任骏2 *

1复旦大学上海医学院 上海

2复旦大学附属中山医院心内科,上海市心血管病研究所 上海

*通讯作者: 任骏,单位:复旦大学附属中山医院心内科,上海市心血管病研究所 上海;

引用本文: 罗宇琦, 任骏 镁在人类心血管疾病中的作用[J]. 国际临床研究杂志, 2024; 8: (8) : 1-8.
Published: 2024/8/19 1:40:59

摘要

镁是人体内含量第四高的阳离子,参与调节心血管功能的多个基本生理、生化和细胞过程。镁对于血管平滑肌细胞、内皮细胞和心肌细胞的正常功能至关重要。血清镁异常是高血压、动脉粥样硬化、冠状动脉疾病、心力衰竭和心律失常等多种发病机制中的关键因子,可能增加不良心血管事件的发生风险。本文旨在探讨镁在人类心血管病中的作用及其相关机制,并对镁的补充提供合理建议。

关键词: 镁;心血管疾病;高血压;冠心病;心律失常

Abstract

Magnesium is the fourth most abundant cation in the human body and plays a significant role in several fundamental physiological, biochemical and cellular processes involved in the regulation of cardiovascular function. It is essential for the normal function of vascular smooth muscle cells, endothelial cells, and cardiomyocytes. Abnormal serum magnesium levels are a key factor in the pathogenesis of various cardiovascular conditions, including hypertension, atherosclerosis, coronary artery disease, heart failure and arrhythmias, and may increase the risk of adverse cardiovascular events. This mini-review aims to explore the role of magnesium and its associated mechanisms in human cardiovascular disease, hoping to provide rational recommendations for magnesium supplementation.

Key words: Magnesium; Cardiovascular disease; Hypertension; Coronary heart disease; Arrhythmia

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