Clinical significance of difference of D-dimer and FIB levels in patients with different fracture sites
不同部位骨折患者 D-二聚体、FIB水平差异的临床意义

摘要

目的 研究不同部位骨折病人的D-二聚体、纤维蛋白原（FIB）数值的临床意义。方法 随机选用 2022年6至2024年6月淮安市第一人民医院分院收治的81例骨折患者，把数据收入骨折组（髌骨骨折10例，股骨骨折8例，肋骨骨折20例，胸椎骨骨折26例，指骨骨折11例，趾骨骨折6例），同时随机选取这时间段中在淮安市第一人民医院健康检查者70例，把数据放入对照组，比较骨折组与对照组 D- 二聚体、纤维蛋白原（FIB）数值以及两组数据的阳性检测率。结果 骨折组病人D-二聚体、纤维蛋白原结果相较对照组更高（P＜ 0.05）；骨折组中股骨、胫骨和腓骨、椎骨和肋骨骨折患者D-二聚体、FIB水平均高于对照组（P＜ 0.05）；骨折组中患者不同部位骨折程度D-二聚体、FIB 及D-二聚体、FIB阳性检出率差异均有统计学意义，并且随着病情程度的加重，病人D-二聚体、FIB数值显著增高（P＜ 0.05）。结论 不同部位骨折患者 D-二聚体、FIB结果变化明显，随着病情的进展 D-二聚体与 FIB水平增高，骨折患者的D-二聚体、 FIB 数值与健康者之间存在明显差异，可将两者合并作为继发纤溶检测标志物之一供临床参考。

Abstract

Objective To investigate the clinical significance of D-dimer and fibrinogen (FIB) levels in patients with different fracture sites.
Methods 81 patients with fracture from the Branch Hospital of Huai’an First People’s Hospital from June 2022 to June 2024 were enrolled in this study. The fracture group included 10 patella fractures, 8 femur fractures, 20 rib fractures, 26 thoracic vertebrae fractures, 11 phalanges fractures and 6 phalanges fractures. At the same time, 70 cases of health examination from the Branch Hospital of Huai’an First People’s Hospital were randomly selected as the control group during this period. The values of D-dimer and FIB and the positive detection rate of the two groups were compared.
Results The results of D-dimer and FIB in the fracture group were higher than those in the control group (P < 0.05). The levels of D-dimer and FIB of patients with femur fracture, tibia and fibula fracture, vertebra and rib fracture in the fracture group were higher than those in the control group (P < 0.05). In the fracture group, the D-dimer levels, FIB levels and the positive detection rates of D-dimer and FIB were significantly different in different fracture sites. The values of D-dimer and FIB were significantly increased with the severity of the disease(P < 0.05).
Conclusion   The levels of D-dimer and FIB were significantly different in patients with different fracture sites, and the levels of D-dimer and FIB increased with the progression of the disease. The values of D-dimer and FIB in fracture patients are obviously different from healthy people. The combination of D-dimer and FIB can be used as one of the markers of secondary fibrinolysis for clinical reference.