To explore the improvement of applied hormone drugs in the treatment of abnormal uterine bleedingduring puberty
青春期子宫异常出血止血治疗中应用性激素药物对患者出血情况的改善探讨

摘要

目的 探究青春期子宫异常出血患者治疗中性激素药物的临床效果。方法 选择研究者医院妇产科提供的样本进行研究，共计100例青春期子宫异常出血患者，入组时间2023年1月~2024年1月。随机分2组，数字表法。对照组予以单纯雌激素治疗，观察组则联用复方短效口服避孕药。比较两组治疗效果、出血改善情况、不良反应发生率以及治疗前后性激素水平。结果 观察组治疗有效率100.00%，较对照组高（χ2=4.1667；P<0.05）。观察组出血控制时间（1.12±0.46）d、完全止血时间（2.12±0.74）d较对照组短，出血量（110.12±10.12）mL较对照组少（T=7.2635；T=7.0935；T=6.7894；P<0.05）。观察组不良反应发生率8.00%略高于对照组，但差异比较（χ2=0.1536；P>0.05）。观察组治疗后E2水平为（240.12±21.36）pmol/L、FSH水平为（5.32±0.72）IU/L、LH水平为（3.25±0.66）IU/L、P水平为（2.23±0.66）nmol/L，较对照组低（T=8.5084；T=15.7610；T=12.4819；T=8.1807；P<0.05）。结论 青春期子宫异常出血治疗中，性激素药物疗效理想，可改善患者性激素水平，快速控制出血，且治疗安全性较高，值得推广。

Abstract

Objective To explore the clinical effect of sex hormone drugs on adolescent patients with abnormal uterine bleeding.
Methods The samples provided by the department of Obstetrics and Gynecology of the investigator hospital was selected to study a total of 100 adolescent patients with abnormal uterine bleeding, enrolled from January 2023 to January 2024. Randomized into 2 groups, numerical table method. The control group was treated with estrogen alone, while the observation group was combined with compound short-acting oral contraceptives. Treatment effects, improvement in bleeding, incidence of adverse reactions, and sex hormone levels before and after treatment were compared between the two groups.
Results The response rate of the observation group was 100.00%, higher than that of the control group (χ2=4.1667; P<0.05）。The bleeding control time in the observation group (1.12±0.46) d, complete hemostasis (2.12±0.74) d was shorter than the control group (110.12±10.12) mL less than the control group (T=7.2635; T=7.0935; T=6.7894; P <0.05). The incidence of adverse reactions in the observation group was 8.00% slightly higher than that in the control group, but the difference was compared (χ2=0.1536; P>0.05）。E2 was (240.12±21.36) pmol/L, FSH (5.32±0.72) IU / L, and LH (3.25 ± 0.66) IU / L, and P (2.23 ± 0.66) nmol / L, lower than the control group (T=8.5084; T=15.7610; T=12.4819; T=8.1807; P <0.05).
Conclusion   In the treatment of abnormal uterine bleeding in puberty, sex hormone drugs have ideal efficacy, which can improve the sex hormone level of patients, and control the bleeding quickly, and the treatment safety is high, which is worth popularizing.