Clinical curative effect of 5-amino-ketovalerate photodynamic combined with intense pulsed light on moderate and severe acne
5-氨基酮戊酸光动力联合强脉冲光治疗中重度痤疮临床疗效观察

摘要

目的 观察5-氨基酮戊酸光动力（5-ALA-PDT）联合强脉冲光治疗中重度痤疮的疗效与安全性，探讨治疗痤疮的有效临床方案及防治疤痕形成方法。方法 将60例中重度痤疮患者，通过分组方式将其分为试验组和对照组各30例，试验组采用5-氨基酮戊酸联合强脉冲光治疗，对照组用5-氨基酮戊酸光动力，每4周治疗1次，连续3次。分别于第2周、第4周、第6周进行阶段性观察，如有不良反应及时跟进和调正。结果 试验组和对照组，在第4周、第6周痤疮患者痊愈率和有效率均有量效意义，分均有所下降（P＜0.05），差异有统计学意义；3个月随访试验组有效率达96%，治疗后结节ECCA及DLQI评分显著降低（P＜0.05）。患者术中出现轻度疼痛，术后出现红斑、干燥紧绷及水肿，经对症处理后3～12 d缓解消退。结论 中重度痤疮采用光动力联合强脉冲光治疗效果显著，患者满意度高，安全性好，值得临床推广应用。

Abstract

Objective To observe the efficacy and safety of 5-aminoketone valerate photodynamic (5-ALA-PDT) combined with intense pulse light in the treatment of moderate and severe acne, to explore the effective clinical treatment of acne and the prevention of scar formation.
Methods 60 patients with moderate and severe acne were divided into test group and control group. The test group was treated with 5-aminovalerate combined with intense pulse light, and the control group was treated with 5-aminoone valerate photodynamic once every 4 weeks for 3 consecutive times. Observe observation in week 2, week 4 and week 6 respectively, and timely follow up and correct adverse reactions.
Results In the test and control groups, the recovery rate and response rate of acne patients at weeks 4 and 6 decreased (P <0.05); the 3-month follow-up response rate was 96%, and the ECCA and DLQI scores were significantly decreased after treatment (P <0.05). The patient experienced mild intraoperative pain, postoperative erythema, dry tension and edema, and subsided from 3 to 12 d after symptomatic treatment.
Conclusion   Treatment with moderate and severe acne has remarkable effect, high patient satisfaction and good safety, which is worthy of clinical promotion and application.