Clinical value of peripheral blood NLR, MLR, PLR detection in the diagnosis of epithelial ovarian cancer
外周血NLR、MLR、PLR检测在上皮性卵巢癌诊断中的临床应用价值研究

摘要

目的 探讨外周血中中性粒细胞和淋巴细胞比值（NLR）、单核细胞和淋巴细胞比值（MLR）、血小板和淋巴细胞比值（PLR）在上皮性卵巢癌诊断中的临床应用价值。方法 回顾性分析2022年3月至2023年9月在本院接受卵巢癌筛查和治疗160例患者的临床资料，将其中上皮性卵巢癌患者80例作为卵巢癌组，健康体检者80例作为对照组。通过比较两组患者外周血的NLR、MLR、PLR水平，利用受试者工作特征（ROC）曲线评价NLR、MLR、PLR在上皮性卵巢癌诊断中的敏感性、特异性、准确性，评估这些指标在临床诊断中的效能。结果 卵巢癌组的NLR、MLR、PLR水平均显著高于对照组，差异具有统计学意义（P<0.05）。NLR、MLR、PLR单独诊断上皮性卵巢癌的曲线下面积（AUC）分别为0.662（95%CI：0.549～0.782）、0.751（95%CI：0.632～0.853）、0.685（95%CI：0.590～0.807），而三者联合诊断的AUC为0.787（95%CI：0.702～0.878）。在单项指标的诊断效能方面，NLR、MLR、PLR均表现出一定敏感性和特异性，但联合检测表现出更高的准确性（46.20%）。结论 外周血NLR、MLR、PLR检测在上皮性卵巢癌诊断中显示出了明显的临床应用潜力，联合检测可提升诊断准确性和效率，为医生提供更全面、准确的诊断依据。

Abstract

Objective To investigate the clinical value of neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratio (PLR) in peripheral blood in the diagnosis of epithelial ovarian cancer.
Methods Clinical data of 160 patients who received ovarian cancer screening and treatment in our hospital from March 2022 to September 2023 were retrospectively analyzed, including 80 patients with epithelial ovarian cancer as the ovarian cancer group and 80 healthy subjects as the control group. By comparing the levels of NLR, MLR and PLR in peripheral blood of the two groups, the sensitivity, specificity and accuracy of NLR, MLR and PLR in the diagnosis of epithelial ovarian cancer were evaluated by receiver operating characteristic (ROC) curve, and the efficacy of these indicators in clinical diagnosis was evaluated.
Results The levels of NLR, MLR and PLR in ovarian cancer group were significantly higher than those in control group, with statistical significance (P<0.05). The area under the curve (AUC) of NLR, MLR and PLR for the diagnosis of epithelial ovarian cancer alone were 0.662 (95%CI: 0.549 ~ 0.782), 0.751 (95%CI: 0.632 ~ 0.853) and 0.685 (95%CI: 0.549 ~ 0.853), respectively. 0.590 ~ 0.807), while the AUC of the combined diagnosis was 0.787 (95%CI: 0.702 ~ 0.878). NLR, MLR and PLR showed certain sensitivity and specificity in the diagnostic efficiency of single index, but the combined detection showed higher accuracy (46.20%).
Conclusion   Peripheral blood NLR, MLR, PLR detection shows obvious clinical application potential in the diagnosis of epithelial ovarian cancer. Combined detection can improve the diagnostic accuracy and efficiency, and provide doctors with more comprehensive and accurate diagnosis basis.