Observation of the therapeutic effect and safety of aspirin and clopidogrel on elderly coronary heart disease
阿司匹林和氯吡格雷对老年冠心病的治疗效果及安全性观察

摘要

目的 分析对老年冠心病的患者应用阿司匹林和氯吡格雷治疗的效果。方法 抽选2021年3月-2023年3月于我院就诊的老年冠心病患者80例，以分层随机法分40例为对照组采取阿司匹林治疗，另外40例为观察组于阿司匹林基础上增加氯吡格雷治疗，对比两组患者治疗前后抗凝效果和血小板功能、不良反应发生率；结果 治疗前，两组抗凝指标、血小板功能差异不显著，P﹥0.05。治疗后观察组指标优于对照组，差异显著，P﹤0.05。而不良反应发生率上，两组无明显差异，P﹥0.05。结论 对老年冠心病患者实施阿司匹林和氯吡格雷治的效果较好，安全性高的同时药效显著，可减少血小板聚集，预防血栓性疾病，延缓疾病进展。

Abstract

Objective To analyze the therapeutic effects of aspirin and clopidogrel on elderly patients with coronary heart disease.
Methods 80 elderly patients with coronary heart disease who visited our hospital from March 2021 to March 2023 were randomly divided into a control group of 40 cases using a stratified random method and treated with aspirin. The other 40 cases were treated with clopidogrel in addition to aspirin in the observation group. The anticoagulant effect, platelet function, and incidence of adverse reactions were compared between the two groups before and after treatment;
Results Before treatment, there was no significant difference in anticoagulant indicators and platelet function between the two groups, P>0.05. After treatment, the indicators of the observation group were better than those of the control group, with a significant difference, P<0.05. There was no significant difference in the incidence of adverse reactions between the two groups, P>0.05.
Conclusion   The use of aspirin and clopidogrel in the treatment of elderly patients with coronary heart disease has a good effect, high safety, and significant efficacy. It can reduce platelet aggregation, prevent thrombotic diseases, and delay disease progression.