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国际临床研究杂志

International Journal of Clinical Research

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International Journal of Clinical Research. 2024; 8: (6) ; 10.12208/j.ijcr.20241217 .

Causal relationship between gastroesophageal reflux disease and risk of depression: a Mendelian randomization study in a European population
胃食管反流病与抑郁发生风险的因果关系：一项欧洲人群的孟德尔随机化研究

作者： 马笑盈, 毛孝周, 马驰, 王鑫鑫, 罗江焰, 付新年, 郑盛 *, 杨涓

大理大学第二附属医院（云南省第三人民医院） 云南昆明

*通讯作者： 郑盛,单位：大理大学第二附属医院（云南省第三人民医院） 云南昆明；

引用本文: 马笑盈, 毛孝周, 马驰, 王鑫鑫, 罗江焰, 付新年, 郑盛, 杨涓 胃食管反流病与抑郁发生风险的因果关系：一项欧洲人群的孟德尔随机化研究[J]. 国际临床研究杂志, 2024; 8: (6) : 90-95.
Published: 2024/6/29 14:10:55

摘要

目的 采用一项欧洲人群的孟德尔随机化研究方法评估胃食管反流病与抑郁发生风险。方法 研究数据来自全基因组关联研究（genome-wide association study，GWAS）汇总数据集，其中胃食管反流病数据包含602604例样本，抑郁数据包含357957例样本，选取77个与胃食管反流病密切相关的遗传位点作为工具变量。分别使用MR Egger、Weighted median、Inverse variance weighted、Simple mode、Weighted mode五种方法进行两样本孟德尔随机化分析，以OR值评估胃食管反流病与抑郁发生风险的因果关系。同时采用异质性检验、多效性检验，leave-one-out进行敏感性分析。结果 MR Egger方法分析结果显示胃食管反流病与抑郁发生风险之间呈显著正相关，比值比（odds ratio，OR）为1.257[95%可信区间（confidence interval，CI）：1.067-1.479；P＜0.007]；Weighted median方法结果分析显示了相似的因果关系（odds ratio，OR）为1.227[95%可信区间（confidence interval，CI）：1.192-1.263；P＜0.007]。此外，漏斗图、散点图、森林图均没有观察到水平多效性和异质性。结论 研究表明，胃食管反流病与抑郁发生风险之间存在正向因果关系。

关键词： 胃食管反流病；抑郁；孟德尔随机化

Abstract

Objective To evaluate the risk of gastroesophageal reflux disease (GERD) and depression in a European population using Mendelian randomization.
Methods Data were collected from the genome-wide association study (GWAS) pooled dataset, including 602,6004 cases of GERD and 357,957 cases of depression. A total of 77 genetic loci closely related to gastroesophageal reflux disease were selected as instrumental variables. Five methods, namely MR Egger, Weighted median, Inverse variance weighted, Simple mode and Weighted mode, were used for the two-sample Mendelian randomization analysis. The OR value was used to evaluate the causal relationship between gastroesophageal reflux disease and the risk of depression. At the same time, heterogeneity test, pleiotropy test and leave-one-out were used for sensitivity analysis.
Results The analysis results of MR Egger method showed that there was a significant positive correlation between the risk of GERD and depression, and the odds ratio (OR) was 1.257[95% confidence interval (CI): 1.067-1.479; P < 0.007]. Weighted median analysis showed a similar causality ratio (OR) of 1.227[95% confidence interval (CI): 1.192-1.263; P < 0.007]. In addition, horizontal pleiotropy and heterogeneity were not observed in funnel plot, scatter plot and forest plot.
Conclusion   There is a positive causal relationship between gastroesophageal reflux disease and the risk of depression.

Key words： Gastroesophageal reflux disease; Depression; Mendelian randomization

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