International Journal of Clinical Research
International Journal of Clinical Research. 2024; 8: (5) ; 10.12208/j.ijcr.20240158 .
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中国药科大学 江苏南京
*通讯作者： 余伯阳,单位：中国药科大学 江苏南京；
缺血性脑卒中，也称脑梗死。是由于各种病因引发的大脑血液供应不足而造成脑组织缺氧性坏死的一种严重疾病。作为脑血管疾病中的一大类，缺血性脑卒中在全球范围内都是主要的健康威胁。中医证型是中医对疾病在发展过程中病理状态所做的概况，是中医诊断与治疗的关键与基础。代谢组学，作为系统生物学的一个重要分支，主要研究生物体内所有代谢物的变化。代谢物，是生物体内生化反应的产物或底物，直接反映了细胞的生命活动状态。中医素有“内病外显”之说，意味着疾病的外在证型必然有其内在的病理基础。本文从代谢组学为基础，探讨了代谢组学针对不同中医证型的缺血性脑卒中的生物标志物的发掘的进展。
Ischemic stroke, also known as cerebral infarction. It is a serious disease of hypoxic necrosis of brain tissue caused by insufficient blood supply to the brain caused by various causes. As a major category of cerebrovascular diseases, ischemic stroke is a major health threat worldwide. TCM syndrome type is the general situation of the pathological state of the disease in the process of development, which is the key and basis of TCM diagnosis and treatment. Metabolomics, as an important branch of systems biology, mainly studies the changes of all metabolites in living organisms. Metabolites are the products or substrates of biochemical reactions in organisms, which directly reflect the life activity state of cells. Traditional Chinese medicine is known as the "internal disease outward appearance", which means that the external syndromes of diseases must have their internal pathological basis. Based on metabolomics, this paper discusses the development of biomarkers for ischemic stroke in different TCM syndromes.
[1] Pandian, Jeyaraj D., et al. "Prevention of stroke: a global perspective." The Lancet 392.10154 (2018): 1269-1278.
[2] 刘兵兵,徐雅,刘政申,等.基于《黄帝内经》“时间医学-生命节律”探讨预防缺血性脑卒中[J].辽宁中医药大学学报,2018,20(01):100-102.
[3] Johnson, Caroline H., Julijana Ivanisevic, and Gary Siuzdak. "Metabolomics: beyond biomarkers and towards mechanisms." Nature reviews Molecular cell biology 17.7 (2016): 451-459.
[4] Patti, Gary J., Oscar Yanes, and Gary Siuzdak. "Metabolomics: the apogee of the omics trilogy." Nature reviews Molecular cell biology 13.4 (2012): 263-269.
[5] Wang, Tianyu, et al. "Functional metabolomics innovates therapeutic discovery of traditional Chinese medicine derived functional compounds." Pharmacology & Therapeutics 224 (2021): 107824.
[6] Markus H S, Bevan S. Mechanisms and treatment of ischaemic stroke—insights from genetic associations[J]. Nature Reviews Neurology, 2014, 10(12): 723-730.
[7] Regenhardt R W, Das A S, Lo E H, et al. Advances in understanding the pathophysiology of lacunar stroke: a review[J]. JAMA neurology, 2018, 75(10): 1273-1281.
[8] 胡星遥,刘红宁,严小军,等.代谢组学在中医证型中的应用探析[J].世界科学技术-中医药现代化,2021,23(04): 1242-1250.
[9] 李婧,陈梓焜,马燕渝,等.基于GC-TOF-MS结合代谢组学分析阳虚证缺血性脑卒中生物标志物的研究[J].湖南中医杂志,2022,38(01):6-10.
[10] 古金晓. 缺血性脑卒中始发态气虚证临床特点、判别模型构建及基于代谢组学的生物学研究[D].北京中医药大学,2022.
[11] 荣立洋,李毓秋.基于代谢组学分析缺血性中风痰湿证生物标志物特点研究[J].广州中医药大学学报,2020,37(02): 195-200.