International Journal of Clinical Research
International Journal of Clinical Research. 2024; 8: (4) ; 10.12208/j.ijcr.20240133 .
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中国药科大学中药学院中药可追溯与标准化研究中心 江苏南京
*通讯作者： 余伯阳,单位：中国药科大学中药学院中药可追溯与标准化研究中心 江苏南京；
麦冬作为一种滋阴药，在传统中药中占有重要地位。作为麦冬皂苷中的主要苷元，鲁斯可皂苷元具有明显的抗心血管疾病、急性肺损伤、预防血脑屏障功能障碍、抗肿瘤、抗炎等多种药理活性。本文重点综述近年来有关鲁斯可皂苷元药理活性机制的研究进展，着重介绍抗心脑血管疾病、改善学习记忆障碍、抗肿瘤、抗炎、免疫调节、改善肝肺病理性损伤等药理作用，以期为今后对鲁斯可皂苷元的深入研究和开发利用提供参考。
Ophiopogon, as a Yin nourishing medicine, plays an important role in traditional Chinese medicine. As the main aglycone in ophiopogon saponins, Ruscogenin has obvious pharmacological activities such as anti-cardiovascular disease, acute lung injury, prevention of blood-brain barrier dysfunction, anti-tumor, anti-inflammatory and so on. In this paper, the research progress of pharmacological activity mechanism of Luscogenin in recent years was reviewed, and the pharmacological effects of anti-cardiovascular and cerebrovascular diseases, improvement of learning and memory disorders, anti-tumor, anti-inflammatory, immunomodulatory, and improvement of rational injury of liver and lung disease were introduced, so as to provide reference for further research, development and utilization of Luscogenin in the future.
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