International Journal of Clinical Research
International Journal of Clinical Research. 2024; 8: (3) ; 10.12208/j.ijcr.20240087 .
总浏览量: 157
1 四川大学华西第二医院，出生缺陷与相关妇儿疾病教育部重点实验室 四川成都
2 成都医学院第二附属医院·核工业四一六医院 四川成都
*通讯作者： 张帅君,单位： 四川大学华西第二医院，出生缺陷与相关妇儿疾病教育部重点实验室 四川成都；
目的 研究异质性胞核核糖核蛋白D(hnRNPD，AUF1)和p63在食管鳞癌中的表达意义。方法 选取成都医学院第二附属医院•核工业四一六医院于1990年5月2023年11月期间50例胃镜标本和75例手术标本食管鳞癌患者作为研究对象，采用免疫组织化学EnVision法检测AUF1和p63在胃镜标本和手术标本中的表达。结果 研究结果显示，食管鳞癌中AUF1阳性率为83%，P63阳性率为88%。结论 AUF1与p63在食管鳞癌中存在异常表达，AUF1与p63表达可作为食管鳞癌的标志性指标，探索食管鳞癌的发病原理，为这种疾病的诊断与治疗提供参考。
Objective To investigate the expression significance of heterogeneous nuclear ribonucleoprotein D (hnRNPD, AUF1) and p63 in esophageal squamous cell carcinoma. Methods Fifty gastroscopy specimens and 75 surgical specimens of esophageal squamous cell carcinoma patients from the Second Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital, from May 1990 to November 2023 were selected as the research subjects. The expression of AUF1 and p63 in gastroscopy and surgical specimens was detected using immunohistochemical EnVision method. Results The research results show that the positive rate of AUF1 and P63 in esophageal squamous cell carcinoma is 83% and 88%, respectively. Conclusion There is abnormal expression of AUF1 and p63 in esophageal squamous cell carcinoma. The expression of AUF1 and p63 can serve as landmark indicators for esophageal squamous cell carcinoma, exploring the pathogenesis of esophageal squamous cell carcinoma and providing reference for the diagnosis and treatment of this disease.
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