Clinical efficacy of positioning methods in the treatment of advanced esophageal cancerwith linear accelerator emission therapy
定位方法对直线加速器发射治疗晚期食管癌的临床疗效

摘要

目的 分析晚期食管癌开展直线加速器放射治疗时，实施不同定位方法所体现的疗效差别。方法 研究纳入我院确诊并开展直线加速器发射治疗的晚期食管癌患者，时段2022年12月-2023年12月。将全体50例依照随机数字表法划分成两组，每组平均25例。两组均采用直线加速器放射治疗，对照组应用常规钡餐定位，观察组应用CT模拟定位，对比两组治疗效果。结果 观察组在采用CT模拟定位下直线加速器放射治疗后，其客观缓解率、肿瘤标志物水平均优于对照组，组间差异显著（P＜0.05）。两组不良事件发生率差异无统计学意义（P＞0.05）。结论 晚期食管癌开展直线加速器放射治疗时，采取CT模拟定位可使临床疗效进一步提升，改善肿瘤标志物，具备良好安全保障。

Abstract

Objective To analyze the therapeutic effect of different localization methods in linear accelerator radiotherapy for advanced esophageal cancer.
Methods Patients with advanced esophageal cancer diagnosed in our hospital and treated with linear accelerator emission were studied from December 2022. December to December 2023.December. All 50 cases were divided into two groups according to random number table method, with an average of 25 cases in each group. The two groups were treated with linear accelerator radiotherapy, the control group was treated with conventional barium meal positioning, the observation group was treated with CT simulated positioning, and the therapeutic effect of the two groups was compared.
Results The objective response rate and tumor marker level of the observation group were better than those of the control group after linear accelerator radiotherapy with simulated CT positioning, and the differences between the groups were significant (P < 0.05). There was no significant difference in the incidence of adverse events between the two groups (P > 0.05).
Conclusion   In the treatment of advanced esophageal cancer with linear accelerator radiotherapy, CT simulated localization can further improve clinical efficacy, improve tumor markers, and have good safety guarantee.