International Journal of Clinical Research
International Journal of Clinical Research. 2023; 7: (11) ; 10.12208/j.ijcr.20231355 .
总浏览量: 238
1 甘肃泛植制药有限公司 甘肃兰州
2 兰州大学化学化工学院 甘肃兰州
*通讯作者： 陈保华,单位： 兰州大学化学化工学院 甘肃兰州；
甘草为豆科甘草属植物甘草的根和根状茎，具有“众药之王”的美称。光果甘草是甘草属中的一种，国内主要分布在西北地区。二十一世纪以来，由于光果甘草广泛的药理作用，因此在化妆品、保健品、医药等方面广为人知，其主要作用包括抗氧化、抗炎、抗菌、抗病毒、保肝等。其中，光果甘草的代表性成分光甘草定由于强大的美白与抗氧化功效，已被谷雨为首的化妆品公司作为美白系列产品主打成分，充分聚焦研发者与消费者的目光。另外，光果甘草中以甘草酸为代表的三萜皂苷类成分具有显著的抗炎、抗过敏、抗病毒等作用，如已上市的复方甘草酸苷片及化妆品中常用的甘草酸二钾等。本文将展开综述光甘草定的药理作用。
Licorice is the root and rhizomes of licorice leguminous plant, and has the laudatory name of "King of all medicines". Glycyrrhiza glabra is a kind of glycyrrhiza genus, mainly distributed in northwest China. Since the 21st century, due to the extensive pharmacological effects of licorice, it is widely known in cosmetics, health products, medicine and other aspects, its main effects include antioxidant, anti-inflammatory, antibacterial, antiviral, liver protection and so on. Among them, glycyrrhetin, the representative ingredient of glycyrrhetin, has been used as the main ingredient of whitening products by cosmetics companies led by Guyu due to its strong whitening and antioxidant effects, fully focusing on the eyes of developers and consumers. In addition, the triterpenoid saponins represented by glycyrrhizic acid in glycyrrhizin have significant anti-inflammatory, anti-allergic and anti-viral effects, such as compound glycyrrhizin tablets and dipotassium glycyrrhizinate commonly used in cosmetics. This article will review the pharmacological effects of glabridine.
[1] 国家药典委员会.中华人民共和国药典:一部[S]. 北京:中国医药科技出版社,2020:155-168.
[2] Vaya J, Belinky P A, Aviram M. Antioxidant constituents from licorice roots: Isolation, structure elucidation and antioxidative capacity toward LDL oxidation [J]. Free Radic Biol Med, 1997, 23(2): 302-313.
[3] 王瑞雪,赵珍,钟雁等.几种常用美白剂协同作用研究[J].日用化学工业,2014,44(10):572-576.
[4] 刘新民.光果甘草——化妆品成分中的一支奇葩[J]. 日用化学工业信息, 2003(19):2.
[5] 骆从艳,慕春海,王园姬,等.光甘草定的制备及其对蘑菇酪氨酸酶的抑制作用[J].石河子大学学报(自然科学版), 2010,28(04):478-482.
[6] 谢琳琳,高振珅,周宏,等.光甘草定的提取分离方法、检测方法及其制剂的研究进展[J].中国药房,2018,29(21): 3009-3013.
[7] 林恋竹,焦铭.光果甘草叶中性多糖结构表征及抗氧化活性研究[J].现代食品科技,2016,32(01):106-110.
[8] 谢毛成,丁家宜,李刚.光果甘草与乌拉尔甘草清除活性氧能力的比较[J].植物资源与环境学报,2003,(01):29-31.
[9] Shinu P, Gupta GL, Sharma M, et al. Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential. Plants (Basel). 2023 Mar 1;12(5):1086.
[10] Ge B, Yang D, Wu X, Zhu J, Wei W, Yang B. Cytoprotective effects of glycyrrhetinic acid liposome against cyclophosphamide-induced cystitis through inhibiting inflammatory stress. Int Immunopharmacol. 2018 Jan;54: 139 -144.
[11] Kazlauskaite JA, Matulyte I, Marksa M, et al. Extracts and Myristica fragrans Houtt. Essential Oil in Microcapsules. Pharmaceutics. 2023 Jan 30;15(2):464.
[12] 赵全民,于录,邓旭明,等.中药单体化合物光甘草定的体外抗菌活性研究[J].中国预防兽医学报,2010,32(03):225-227.
[13] 魏娟花. 光果甘草三萜皂苷类化学成分及活性研究[D].南京中医药大学,2015.
[14] S. Asgary, N. Jafari Dinani, H. Madani, et al. Effect of Glycyrrhiza glabra Extract on Aorta Wall Atherosclerotic Lesion in Hypercholesterolemic Rabbits[J]. Pakistan Journal of Nutrition, 2007,6(4).
[15] 谭春江,吴岩斌,林如辉,等.光果甘草定对ox-LDL损伤性人主动脉内皮细胞保护的机制研究[J].中医药学报,2014, 42(02):16-19.
[16] 许谙,章荣华,徐彩菊.光甘草定对HUVEC细胞粘附分子ICAM-1表达影响及作用机理研究[J].现代实用医学,2008,(09):672-675.
[17] Ahmad Rizwan, Alqathama Aljawharah, Aldholmi Mohammed, et al. Biological Screening of Glycyrrhiza glabra L. from Different Origins for Antidiabetic and Anticancer Activity[J]. Pharmaceuticals, 2022,16(1).
[18] 朱子博,樊金玲,程源斌,等.光果甘草提酸废渣萃取物降血糖活性的研究[J].食品科技,2019,44(06):233-241.
[19] 赵焱.光甘草定在MPTP帕金森病小鼠的神经保护作用及机制研究[D].武汉大学,2017.
[20] Wang Hao, Ge Xuhui, Qu Huiheng, et al. Glycyrrhizic Acid Inhibits Proliferation of Gastric Cancer Cells by Inducing Cell Cycle Arrest and Apoptosis.[J]. Cancer management and research, 2020,12(default).
[21] 智信,陈晓,苏佳灿.甘草次酸药理作用研究进展[J].现代中西医结合杂志,2019,28(25):2847-2850.
[22] 罗祖良,李倩,覃洁萍,等.光果甘草的研究进展[J].中草药,2011,42(10):2154-2158.