International Journal of Clinical Research
International Journal of Clinical Research. 2023; 7: (12) ; 10.12208/j.ijcr.20230356 .
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暨南大学第二临床医学院 深圳
*通讯作者： 叶喜阳,单位：暨南大学第二临床医学院 深圳；
常见的妇科恶性肿瘤包括子宫颈癌、子宫内膜癌及卵巢癌，无论哪种肿瘤都对女性身心健康造成了极大的危害，且每年的发病率都有上升趋势。明确肿瘤的发病机制，探索与肿瘤发生、发展甚至预后相关的生物靶标，对于恶性肿瘤的认识与治疗有着重要的意义。泛素化特异性蛋白酶14（ubiquitin-specific protease14, USP14）的生物学作用涉及到细胞周期、细胞凋亡、信号传导等多个方面。其通过调控泛素-蛋白质降解途径，影响细胞内许多蛋白质的稳定性和代谢。USP14被证明与许多恶性肿瘤发生、发展有密切关系，是恶性肿瘤发展、治疗与转归的新生物靶标。本文旨在介绍USP14在常见妇科恶性肿瘤中的研究现状、发生机制及其在肿瘤化疗耐药中的作用。
The common gynecological malignancies include cervical cancer, endometrial cancer and ovarian cancer, which have caused great harm to women's physical and mental health, and the annual incidence rate has an upward trend. Clarifying the pathogenesis of tumors and exploring biological targets related to tumor occurrence, development, and even prognosis are of great significance for the understanding and treatment of malignant tumors. The biological effects of ubiquitin specific protease 14 (USP14) involve multiple aspects such as cell cycle, apoptosis, and signal transduction. It affects the stability and metabolism of many proteins in cells by regulating the ubiquitin protein degradation pathway. USP14 has been proven to be closely related to the occurrence and development of many malignant tumors, and is a new biological target for the development, treatment, and prognosis of malignant tumors. This article aims to introduce the current research status, pathogenesis, and role of USP14 in common gynecological malignant tumors in tumor chemotherapy resistance.
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