International Journal of Clinical Research
International Journal of Clinical Research. 2023; 7: (7) ; 10.12208/j.ijcr.20230267 .
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佳木斯大学附属第一医院 黑龙江佳木斯
*通讯作者： 金梅花,单位：佳木斯大学附属第一医院 黑龙江佳木斯；
心肌结构重构、电重构在心房纤颤及心力衰竭的发生发展中起着重要作用，描述心肌重构最一致的就是心肌纤维化，表现为心肌胶原、细胞外基质沉积，导致心肌电传导障碍以及心肌收缩障碍。许多研究表明，松弛素，作为一种胰岛素样肽类激素，抑制心肌纤维化，降低心脏负荷，拮抗甚至逆转心肌的结构重构及电重构，在心房纤颤及心力衰竭中发挥着调节作用，这些研究结果揭示了松弛素具有巨大的治疗潜力。
Myocardial structural and electrical remodeling play an important role in the occurrence and development of atrial fibrillation and heart failure. The most consistent description of myocardial remodeling is myocardial fibrosis, characterized by the deposition of myocardial collagen and extracellular matrix, leading to myocardial electrical conduction disorders and myocardial contraction disorders. Many studies have shown that Relaxin, as an insulin like Peptide hormone, inhibits myocardial fibrosis, reduces cardiac load, antagonizes and even reverses structural and electrical remodeling of the myocardium, and plays a regulatory role in atrial fibrillation and heart failure. These results reveal that Relaxin has great therapeutic potential.
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