Clinical efficacy of flunarizine hydrochloride in the treatment of migraine
盐酸氟桂利嗪治疗偏头痛的临床疗效

摘要

目的 探讨在偏头痛治疗中采用盐酸氟桂利嗪的临床效果。方法 选取2022年1月到2022年12月我院收治的90例偏头痛患者，随机分成对照组（n=45，尼麦角林片）与研究组（n=45，盐酸氟桂利嗪），对比偏头痛相关症状及疼痛评分、血清指标、血流动力学指标、不良反应发生率、生活质量评分。结果 研究组偏头痛发作次数、发作持续时间、疼痛评分均较少，P＜0.05；研究组TNF-α、ICAM-1、CGRP、IL-1β均较低，5-HT较高，P＜0.05；研究组血流动力学指标较低，P＜0.05；两组不良反应发生率无显著差异，P＞0.05；研究组生活质量评分较高，P＜0.05。结论 在偏头痛治疗中采取盐酸氟桂利嗪效果确切，改善血流动力学，缓解偏头痛症状，提高生活质量。

Abstract

Objective: To explore the clinical effect of flunarizine hydrochloride in the treatment of migraine.
Methods: A total of 90 patients with migraine admitted to our hospital from January 2022 to December 2022 were randomly divided into a control group (n=45, nimergoline tablets) and a study group (n=45, flunarizine hydrochloride). The migraine-related symptoms and pain scores, serum indicators, hemodynamic indicators, incidence of adverse reactions, and quality of life scores were compared.
Results: The frequency, duration, and pain score of migraine attacks in the study group were less (P<0.05); Research group TNF- α、 ICAM-1、CGRP、IL-1 β Both were lower, with a higher 5-HT, P<0.05; The hemodynamic indexes in the study group were lower (P<0.05); There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05); The quality of life score in the study group was higher (P<0.05).
Conclusion  : Flunarizine hydrochloride is effective in the treatment of migraine, improving hemodynamics, alleviating migraine symptoms, and improving quality of life.